{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:40:27Z","timestamp":1790628027936,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Optical coherence tomography (OCT) angiography is a new method to assess the density of the vascular networks. Vascular abnormalities are considered involved in multiple sclerosis (MS) pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the presence of vascular abnormalities in MS and to evaluate their correlation to disease features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 50 MS patients with and without history of optic neuritis (ON) and 46 healthy subjects were included. All underwent spectral domain (SD)-OCT and OCT angiography. Clinical history, Expanded Disability Status Scale (EDSS), Multiple Sclerosis Severity Score (MSSS) and disease duration were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Angio-OCT showed a vessel density reduction in eyes of MS patients when compared to controls. A statistically significant reduction in all SD-OCT and OCT angiography parameters was noticed both in eyes with and without ON when compared with control eyes. We found an inverse correlation between SD-OCT parameters and MSSS ( p\u2009=\u20090.003) and between vessel density parameters and EDSS ( p\u2009=\u20090.007).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We report a vessel density reduction in retina of MS patients. We highlight the clinical correlation between vessel density and EDSS, suggesting that angio-OCT could be a good marker of disease and of disability in MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458517729463","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T06:45:37Z","timestamp":1505976337000},"page":"1706-1714","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":112,"title":["Optical coherence tomography angiography retinal vascular network assessment in multiple sclerosis"],"prefix":"10.1177","volume":"24","author":[{"given":"Roberta","family":"Lanzillo","sequence":"first","affiliation":[{"name":"Multiple Sclerosis Center, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Cennamo","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Criscuolo","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Carotenuto","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"Velotti","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sparnelli","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Cianflone","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Moccia","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Brescia Morra","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"bibr1-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304547"},{"key":"bibr2-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.07.026"},{"key":"bibr3-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.131"},{"key":"bibr4-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1159\/000128103"},{"key":"bibr5-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12720"},{"key":"bibr6-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d6b125"},{"key":"bibr7-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.05.005"},{"key":"bibr8-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260612.51849.ed"},{"key":"bibr9-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199414050-00010"},{"key":"bibr10-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.11.1491"},{"key":"bibr11-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000822"},{"key":"bibr12-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-1549(03)00013-0"},{"key":"bibr13-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-04-01169.1992"},{"key":"bibr14-1352458517729463","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002774"},{"key":"bibr15-1352458517729463","first-page":"530305","volume":"2012","author":"Oberwahrenbrock 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