{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:02:49Z","timestamp":1793419369559,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["PP-1411-02021"],"award-info":[{"award-number":["PP-1411-02021"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Fatigue is a common and debilitating feature of multiple sclerosis (MS) that remains without reliably effective treatment. Transcranial direct current stimulation (tDCS) is a promising option for fatigue reduction. We developed a telerehabilitation protocol that delivers tDCS to participants at home using specially designed equipment and real-time supervision (remotely supervised transcranial direct current stimulation (RS-tDCS)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate whether tDCS can reduce fatigue in individuals with MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Dorsolateral prefrontal cortex left anodal tDCS was administered using a RS-tDCS protocol, paired with 20\u2009minutes of cognitive training. Here, two studies are considered. Study 1 delivered 10 open-label tDCS treatments (1.5\u2009mA;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200915) compared to a cognitive training only condition (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200920). Study 2 was a randomized trial of active (2.0\u2009mA,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200915) or sham (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912) delivered for 20 sessions. Fatigue was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS)\u2014Fatigue Short Form.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and conclusion:<\/jats:title>\n                    <jats:p>\n                      In Study 1, there was modest fatigue reduction in the active group (\u22122.5\u2009\u00b1\u20097.4 vs \u22120.2\u2009\u00b1\u20095.3,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.30, Cohen\u2019s\n                      <jats:italic toggle=\"yes\">d<\/jats:italic>\n                      \u2009=\u2009\u22120.35). However, in Study 2 there was statistically significant reduction for the active group (\u22125.6\u2009\u00b1\u20098.9 vs 0.9\u2009\u00b1\u20091.9,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02, Cohen\u2019s\n                      <jats:italic toggle=\"yes\">d<\/jats:italic>\n                      \u2009=\u2009\u22120.71). tDCS is a potential treatment for MS-related fatigue.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458517732842","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T11:26:37Z","timestamp":1506079597000},"page":"1760-1769","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":125,"title":["Remotely supervised transcranial direct current stimulation for the treatment of fatigue in multiple sclerosis: Results from a randomized, sham-controlled trial"],"prefix":"10.1177","volume":"24","author":[{"given":"Leigh E","family":"Charvet","sequence":"first","affiliation":[{"name":"Department of Neurology, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Dobbs","sequence":"additional","affiliation":[{"name":"Department of Neurology, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Neurology, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marom","family":"Bikson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The City University of New York, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Datta","sequence":"additional","affiliation":[{"name":"Soterix Medical, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren B","family":"Krupp","sequence":"additional","affiliation":[{"name":"Department of Neurology, NYU Langone Medical Center, New York, NY, 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