{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:25:50Z","timestamp":1777937150638,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["B7493-W, R. Spain"],"award-info":[{"award-number":["B7493-W, R. 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Post hoc analysis determined influences of optic neuritis (ON), disease duration, and baseline SD-OCT on annualized atrophy rates and on correlations between OCT and brain atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean RNFL and GCIPL values of patients ( n = 47, mean age = 59 years, mean disease duration = 30 years) were significantly lower among eyes with prior ON than those without (no history of ON (NON)). Annualized RNFL (\u22120.31 \u00b5m\/year) and GCIPL (\u22120.29 \u00b5m\/year) atrophy rates did not differ between ON and NON eyes. Baseline RNFL thickness &gt;75 \u00b5m was associated with greater annualized RNFL atrophy (\u22120.85 \u00b5m\/year). Neither RNFL nor GCIPL atrophy correlated with whole-brain atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study suggests that eyes with and without ON history may be pooled for atrophy analysis in SPMS clinical trials using SD-OCT. Low baseline RNFL, small retinal atrophy rates, and lack of correlation with whole-brain atrophy in this population are important trial design considerations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458517739136","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T10:55:26Z","timestamp":1510052126000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Longitudinal optical coherence tomography study of optic atrophy in secondary progressive multiple sclerosis: Results from a clinical trial cohort"],"prefix":"10.1177","volume":"25","author":[{"given":"Kimberly M","family":"Winges","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, VA Portland Health Care System, Portland, OR, USA\/Department of Neurology, Oregon Health & Science University, Portland, OR, USA\/Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles F","family":"Murchison","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oregon Health & Science University, Portland, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis N","family":"Bourdette","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oregon Health & Science University, Portland, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca I","family":"Spain","sequence":"additional","affiliation":[{"name":"Department of Neurology, VA Portland Health Care System, Portland, OR, USA\/Department of Neurology, Oregon Health & Science University, Portland, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"bibr1-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.41"},{"key":"bibr2-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2010.04.014"},{"issue":"11","key":"bibr3-1352458517739136","first-page":"2520","volume":"40","author":"Parisi V","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr4-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20851"},{"key":"bibr5-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00068-5"},{"key":"bibr6-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24487"},{"key":"bibr7-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827b1a1c"},{"key":"bibr8-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295995.46586.ae"},{"key":"bibr9-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512457844"},{"key":"bibr10-1352458517739136","first-page":"530305","volume":"2012","author":"Oberwahrenbrock T","year":"2012","journal-title":"Mult Scler Int"},{"key":"bibr11-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.02.354"},{"key":"bibr12-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr264"},{"key":"bibr13-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e31829c51f7"},{"key":"bibr14-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70168-X"},{"key":"bibr15-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514523498"},{"key":"bibr16-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.6_Part_2.26"},{"key":"bibr17-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22005"},{"key":"bibr18-1352458517739136","first-page":"277","volume":"131","author":"Henderson AP","year":"2008","journal-title":"Brain"},{"key":"bibr19-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8127-y"},{"key":"bibr20-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000374"},{"key":"bibr21-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20703"},{"key":"bibr22-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1177\/135245859900500409"},{"key":"bibr23-1352458517739136","doi-asserted-by":"publisher","DOI":"10.3109\/01658107.2011.557760"},{"key":"bibr24-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514538110"},{"key":"bibr25-1352458517739136","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"bibr26-1352458517739136","unstructured":"Team RC. 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