{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:26:21Z","timestamp":1777937181118,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The importance of neurodegeneration in multiple sclerosis (MS) is increasingly well recognized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate retinal pathology using optical coherence tomography (OCT) and to investigate possible associations between retinal layers\u2019 thickness and specific patterns of gray matter volume in patients with a new diagnosis of MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 31 patients underwent OCT scans and brain magnetic resonance imaging. In total, 30 controls underwent the same OCT procedure. The association between focal cortical volume and OCT measurements was investigated with voxel-based morphometry (VBM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared to controls, patients\u2019 macular retinal nerve fiber layer (mRNFL), macular ganglion cell layer (mGCL), macular inner plexiform layer (mIPL), and macular ganglion cell-inner plexiform layer (mGCIPL) thickness were significantly reduced ( p\u2009=\u20090.0009, p\u2009=\u20090.0003, p\u2009=\u20090.0049, and p\u2009=\u20090.0007, respectively). Peripapillary RNFL (pRNFL) and temporal sector pRNFL (T-pRNFL) did not show any significant changes, although there was a trend toward T-pRNFL thinning ( p\u2009=\u20090.0254). VBM analysis showed that mGCIPL and pRNFL were significantly correlated with the volume reduction of occipital-parietal cortex ( p\u2009&lt;\u20090.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>mRNFL, mGCL, and mIPL are significantly reduced in MS patients without concomitant pRNFL thinning. These retinal changes show a significant association with cortical regions that are known to be important for visuospatial performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458517740214","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T06:20:02Z","timestamp":1510294802000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":50,"title":["The loss of macular ganglion cells begins from the early stages of disease and correlates with brain atrophy in multiple sclerosis patients"],"prefix":"10.1177","volume":"25","author":[{"given":"Anna M","family":"Pietroboni","sequence":"first","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Dell\u2019Arti","sequence":"additional","affiliation":[{"name":"Ophthalmological Unit, Department of Clinical Sciences and Community Health, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Scarioni","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Carandini","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Arighi","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio G","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena A","family":"De Riz","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Basilico","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Colombi","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Benatti","sequence":"additional","affiliation":[{"name":"Ophthalmological Unit, Department of Clinical Sciences and Community Health, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Triulzi","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio","family":"Scarpini","sequence":"additional","affiliation":[{"name":"Neurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Viola","sequence":"additional","affiliation":[{"name":"Ophthalmological Unit, Department of Clinical Sciences and Community Health, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, 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