{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:24:25Z","timestamp":1777937065678,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Detecting early progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) is clinically relevant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Evaluating magnetic resonance imaging (MRI) changes following natalizumab (NTZ) discontinuation and preceding PML-IRIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>MRIs (including diffusion-weighted imaging (DWI), T2-weighted fluid-attenuated inversion recovery (T2-FLAIR), post-contrast T1-weighted sequences) were performed every week following PML diagnosis in 11 consecutive NTZ-PML patients. PML expansion, punctate lesions, contrast-enhancement, and mass-effect\/edema were evaluated on each MRI sequence, following NTZ discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PML-IRIS occurred from 26 to 89\u2009days after NTZ discontinuation. MRI changes prior to early PML-IRIS appeared significantly more pronounced using DWI compared to T2-FLAIR imaging ( p\u2009&lt;\u20090.003). Two DWI features (marked PML expansion, punctate lesions) systematically preceded contrast-enhancement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Subtle changes may occur on DWI preceding contrast-enhancement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458517750765","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T01:36:34Z","timestamp":1516325794000},"page":"1902-1908","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Magnetic resonance imaging changes following natalizumab discontinuation in multiple sclerosis patients with progressive multifocal leukoencephalopathy"],"prefix":"10.1177","volume":"24","author":[{"given":"J\u00e9r\u00f4me","family":"Hodel","sequence":"first","affiliation":[{"name":"Departments of Neuroradiology, AP-HP, H\u00f4pitaux Universitaires Henri Mondor, Cr\u00e9teil, France; Faculty of Medicine, Universit\u00e9 Paris Est Cr\u00e9teil, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanche","family":"Bapst","sequence":"additional","affiliation":[{"name":"Departments of Neuroradiology, AP-HP, H\u00f4pitaux Universitaires Henri Mondor, Cr\u00e9teil, France\/Faculty of Medicine, Universit\u00e9 Paris Est Cr\u00e9teil, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Outteryck","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU Lille, Lille, France\/University of Lille, CHU Lille, LIRIC-INSERM U995, FHU Imminent, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Verclytte","sequence":"additional","affiliation":[{"name":"Department of Radiology, Saint Philibert Hospital, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Deramecourt","sequence":"additional","affiliation":[{"name":"Department of Pathology, CHU Lille, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Amine","family":"Benadjaoud","sequence":"additional","affiliation":[{"name":"Institute of Radiological Protection and Nuclear Safety (IRSN), Human Health Radiation Protection Unit, Fontenay-aux-Roses, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Pruvo","sequence":"additional","affiliation":[{"name":"University of Lille, CHU Lille, INSERM U1171 - Degenerative and Vascular Cognitive Disorders, F-59045 Lille, France\/Department of Neuroradiology, University of Lille, CHU Lille, F-59000, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Vermersch","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU Lille, Lille, France\/University of Lille, CHU Lille, LIRIC-INSERM U995, FHU Imminent, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Leclerc","sequence":"additional","affiliation":[{"name":"University of Lille, CHU Lille, INSERM U1171 - Degenerative and Vascular Cognitive Disorders, F-59045 Lille, France\/Department of Neuroradiology, University of Lille, CHU Lille, F-59000, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"bibr1-1352458517750765","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822e55e7"},{"key":"bibr2-1352458517750765","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-311411"},{"key":"bibr3-1352458517750765","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828c2fa1"},{"key":"bibr4-1352458517750765","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23676"},{"key":"bibr5-1352458517750765","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513510224"},{"key":"bibr6-1352458517750765","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01362.x"},{"key":"bibr7-1352458517750765","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2024"},{"key":"bibr8-1352458517750765","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002586"},{"key":"bibr9-1352458517750765","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31825caf2c"},{"key":"bibr10-1352458517750765","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-304986"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458517750765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458517750765","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458517750765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:53:16Z","timestamp":1777693996000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458517750765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,18]]},"references-count":10,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1177\/1352458517750765"],"URL":"https:\/\/doi.org\/10.1177\/1352458517750765","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,18]]}}}