{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:25:59Z","timestamp":1777937159949,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2017R1D1A1B03028868"],"award-info":[{"award-number":["NRF-2017R1D1A1B03028868"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We aimed to evaluate the utility of the recently described brain lesion distribution criteria to differentiate multiple sclerosis (MS) from aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein immunoglobulin G-associated encephalomyelitis (MOG-EM) at disease onset in an Asian cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 214 patients who fulfilled the published criteria for MS, NMOSD, or MOG-EM and underwent brain magnetic resonance imaging (MRI) within 3\u2009months of disease onset were enrolled. The brain lesion distribution criteria were defined as the presence of a lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe, or an S-shaped U-fiber lesion, or a Dawson\u2019s finger-type lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Brain lesions were identified in the initial MRI scans of 166\/214 patients. The distribution criteria were applied to these scans (MS ( n = 94), NMOSD ( n = 64), and MOG-EM ( n = 8)). The sensitivity, specificity, and positive and negative predictive values of the criteria for MS versus NMOSD were 79.8%, 87.5%, 90.4%, and 74.7%, and for MS versus MOG-EM these were 79.8%, 100%, 100%, and 29.6%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings suggest that the brain lesion distribution criteria are helpful in distinguishing MS from NMOSD and MOG-EM in an Asian population, even at disease onset.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458518761186","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T08:21:20Z","timestamp":1520410880000},"page":"585-590","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of brain lesion distribution criteria at disease onset in differentiating MS from NMOSD and MOG-IgG-associated encephalomyelitis"],"prefix":"10.1177","volume":"25","author":[{"given":"Jae-Won","family":"Hyun","sequence":"first","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So-Young","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Kosin University, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-June","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Woodhall","sequence":"additional","affiliation":[{"name":"Autoimmune Neurology group, Nuffield Department of Clinical Neurosciences and Oxford University, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarosh R","family":"Irani","sequence":"additional","affiliation":[{"name":"Autoimmune Neurology group, Nuffield Department of Clinical Neurosciences and Oxford University, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Research Institute and Hospital of National Cancer Center, Goyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Waters","sequence":"additional","affiliation":[{"name":"Autoimmune Neurology group, Nuffield Department of Clinical Neurosciences and Oxford University, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,7]]},"reference":[{"key":"bibr1-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000206"},{"key":"bibr2-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"bibr3-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00393-2"},{"key":"bibr4-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.72"},{"key":"bibr5-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001367"},{"key":"bibr6-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182887957"},{"key":"bibr7-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"bibr8-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314005"},{"key":"bibr9-1352458518761186","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2017.13.2.175"},{"key":"bibr10-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000089"},{"key":"bibr11-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000436079.95856.1f"},{"key":"bibr12-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1017\/S0080456800027174"},{"key":"bibr13-1352458518761186","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513506953"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458518761186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458518761186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458518761186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:54:02Z","timestamp":1777694042000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458518761186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,7]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1177\/1352458518761186"],"URL":"https:\/\/doi.org\/10.1177\/1352458518761186","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,7]]}}}