{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:26:38Z","timestamp":1777937198866,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Understanding the long-term effect of alemtuzumab on the immune system of multiple sclerosis (MS) patients is crucial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To report a case of acute sarcoidosis (L\u00f6fgren\u2019s syndrome) in a relapsing-remitting MS patient, 1.5\u2009years after the second course of alemtuzumab treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report:<\/jats:title>\n                    <jats:p>Sarcoidosis was confirmed dermatohistologically, radiologically, and serologically. Analysis of the lymphocyte subpopulations showed a persistent effect of alemtuzumab treatment (CD4\/CD8 ratio increased, absolute lymphocyte count of CD19-positive cells increased while CD3\/4\/8-positive cells were decreased).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our case highlights the profound effect of alemtuzumab on the immune system and its possible risk for autoimmune complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458518771276","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T10:19:56Z","timestamp":1539253196000},"page":"1776-1778","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Acute sarcoidosis in a multiple sclerosis patient after alemtuzumab treatment"],"prefix":"10.1177","volume":"24","author":[{"given":"Jonas","family":"Graf","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital D\u00fcsseldorf, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Ringelstein","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital D\u00fcsseldorf, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaudia","family":"Lepka","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital D\u00fcsseldorf, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Schaller","sequence":"additional","affiliation":[{"name":"Dermatopathologie Duisburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Quack","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis f\u00fcr Radiologie und Nuklearmedizin am Bethesda Krankenhaus, M\u00f6nchengladbach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Peter","family":"Hartung","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital D\u00fcsseldorf, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-9210","authenticated-orcid":false,"given":"Orhan","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"bibr1-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004354"},{"key":"bibr2-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004313"},{"key":"bibr3-1352458518771276","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301926"},{"key":"bibr4-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.12.012"},{"key":"bibr5-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12676"},{"key":"bibr6-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.701"},{"key":"bibr7-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.12.011"},{"key":"bibr8-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06687.x"},{"key":"bibr9-1352458518771276","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-9-201205010-01005"},{"key":"bibr10-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514549398"},{"key":"bibr11-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06324.x"},{"key":"bibr12-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200606-130MS"},{"key":"bibr13-1352458518771276","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.0676"}],"container-title":["Multiple 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