{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:29:05Z","timestamp":1784698145656,"version":"3.55.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["3364A1\/2"],"award-info":[{"award-number":["3364A1\/2"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1107343"],"award-info":[{"award-number":["1107343"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["313901"],"award-info":[{"award-number":["313901"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000924","name":"Multiple Sclerosis Research Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020598","name":"Multiple Sclerosis Western Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020598","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The evidence associating diet and risk of multiple sclerosis is inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We investigated associations between dietary patterns and risk of a first clinical diagnosis of central nervous system demyelination, a common precursor to multiple sclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We used data from the 2003\u20132006 Ausimmune Study, a case\u2013control study examining environmental risk factors for a first clinical diagnosis of central nervous system demyelination, with participants matched on age, sex and study region. Using data from a food frequency questionnaire, dietary patterns were identified using principal component analysis. Conditional logistic regression models ( n\u2009=\u2009698, 252 cases, 446 controls) were adjusted for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, race, education, body mass index and dietary misreporting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified two major dietary patterns \u2013 healthy (high in poultry, fish, eggs, vegetables, legumes) and Western (high in meat, full-fat dairy; low in wholegrains, nuts, fresh fruit, low-fat dairy), explaining 9.3% and 7.5% of variability in diet, respectively. A one-standard deviation increase in the healthy pattern score was associated with a 25% reduced risk of a first clinical diagnosis of central nervous system demyelination (adjusted odds ratio 0.75; 95% confidence interval 0.60, 0.94; p\u2009=\u20090.011). There was no statistically significant association between the Western dietary pattern and risk of a first clinical diagnosis of central nervous system demyelination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Following healthy eating guidelines may be beneficial for those at high risk of multiple sclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458518793524","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T11:54:37Z","timestamp":1533642877000},"page":"1514-1525","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination"],"prefix":"10.1177","volume":"25","author":[{"given":"Lucinda J","family":"Black","sequence":"first","affiliation":[{"name":"School of Public Health, Curtin University, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Rowley","sequence":"additional","affiliation":[{"name":"School of Public Health, Curtin University, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Sherriff","sequence":"additional","affiliation":[{"name":"School of Public Health, Curtin University, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Pereira","sequence":"additional","affiliation":[{"name":"School of Public Health, Curtin University, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Louise","family":"Ponsonby","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, The University of Melbourne, Melbourne, VIC, Australia\/National Centre for Epidemiology & Population Health, Research School of Population Health, The Australian National University, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn M","family":"Lucas","sequence":"additional","affiliation":[{"name":"National Centre for Epidemiology & Population Health, Research School of Population Health, The Australian National University, Canberra, ACT, Australia\/Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, WA, 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