{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:42:38Z","timestamp":1790682158058,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the impact of age on recovery from multiple sclerosis relapses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Increasing disability in multiple sclerosis is a consequence of progressive disease and incomplete relapse recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The first and last-ever relapse data (357 relapses in 193 patients) from the Olmsted County population-based multiple sclerosis cohort were systematically reviewed for age, fulminance, location (optic nerve, brainstem\/cerebellar, spinal cord), peak deficit, and maximum recovery. Three different relapse-outcome measures were studied both as paired analyses and as an overall group effect: change from peak deficit to maximum recovery in raw functional system score related to the relapse (\u0394FSS), a previously published FSS-based relapse-impact model, and change from peak deficit to maximum recovery in Extended Disability Status Scale (\u0394EDSS) score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Older age was linearly associated with worse recovery in the \u0394FSS outcome ( p\u2009=\u20090.002), \u0394EDSS outcome ( p\u2009&lt;\u20090.001), and the FSS-based relapse-impact model ( p\u2009&lt;\u20090.001). A multivariate analysis of \u0394FSS outcome linked poor recovery to older age ( p\u2009=\u20090.015), relapse location (transverse myelitis or brainstem\/cerebellar syndrome; p\u2009&lt;\u20090.001), and relapse fulminance ( p\u2009=\u20090.004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Multiple sclerosis-relapse recovery declines in a linear fashion with increased age, which should be considered when making treatment decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458518800815","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T06:15:24Z","timestamp":1539152124000},"page":"1754-1763","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":67,"title":["Age is a critical determinant in recovery from multiple sclerosis relapses"],"prefix":"10.1177","volume":"25","author":[{"given":"Brittani L","family":"Conway","sequence":"first","affiliation":[{"name":"Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, and Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA\/ HealthPartners Neuroscience Center, Saint Paul, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Zeydan","sequence":"additional","affiliation":[{"name":"Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, and Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA\/ Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011fur","family":"Uyguno\u011flu","sequence":"additional","affiliation":[{"name":"Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, and Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA\/ Cerrahpa\u015fa Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Novotna","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA\/ Polyclinic Medicina Plus, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aksel","family":"Siva","sequence":"additional","affiliation":[{"name":"Cerrahpa\u015fa Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J","family":"Pittock","sequence":"additional","affiliation":[{"name":"Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, and Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, and Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhun H","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, and Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"bibr1-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001856"},{"key":"bibr2-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl007"},{"key":"bibr3-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24497"},{"key":"bibr4-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.067"},{"key":"bibr5-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512451510"},{"key":"bibr6-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86198"},{"key":"bibr7-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-009-0238-0"},{"key":"bibr8-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp280"},{"key":"bibr9-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03529.x"},{"key":"bibr10-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511431725"},{"key":"bibr11-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507084650"},{"key":"bibr12-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000096175.39831.21"},{"key":"bibr13-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000342458.39625.91"},{"key":"bibr14-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000094316.90240.EB"},{"key":"bibr15-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.1.28"},{"key":"bibr16-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"bibr17-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"bibr18-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"bibr19-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2008.01076.x"},{"key":"bibr20-1352458518800815","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.065"},{"key":"bibr21-1352458518800815","first-page":"22","volume":"2015","author":"Novotna 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