{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:02:39Z","timestamp":1793998959965,"version":"4.8.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e1 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>MOG-IgG-associated optic neuritis, encephalitis and myelitis (MONEM) is a recently recognized group of inflammatory central nervous system (CNS) disorders distinct from multiple sclerosis and neuromyelitis optica spectrum disorders. Limited data are available regarding the predictors of relapse in this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to evaluate the longitudinal serostatus of patients with MOG-IgG and to correlate serostatus with long-term clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Of 574 consecutive patients who presented with demyelinating inflammatory CNS disorders, we included 31 patients who were MOG-IgG-positive. Patients with MOG-IgG were followed up from 2011 to 2017 at the School of Medicine, University of S\u00e3o Paulo, Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Relapsing disease occurred in 23 out of 31 patients (74%), while 8 (26%) exhibited a monophasic course. All monophasic patients, as well as the majority of relapsing patients, became seronegative during clinical remission. Patients exhibiting disease activity in the last 2\u2009years were more likely to remain positive, with higher medium titres than those found in patients in clinical remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MOG-IgG patients usually present with a relapsing course, and the risk of relapse was associated with longitudinally persistent MOG-IgG seropositivity. In contrast, patients who experienced a single attack became spontaneously seronegative for MOG-IgG during long-term follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458518811597","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T08:05:03Z","timestamp":1542009903000},"page":"1907-1914","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":65,"title":["Persistent MOG-IgG positivity is a predictor of recurrence in MOG-IgG-associated optic neuritis, encephalitis and myelitis"],"prefix":"10.1177","volume":"25","author":[{"given":"Luana Michelli","family":"Oliveira","sequence":"first","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HC-FMUSP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira Luisa","family":"Ap\u00f3stolos-Pereira","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HC-FMUSP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-0264","authenticated-orcid":false,"given":"Milena Sales","family":"Pitombeira","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HC-FMUSP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique","family":"Bruel Torretta","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HC-FMUSP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagoberto","family":"Callegaro","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HC-FMUSP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7695-6020","authenticated-orcid":false,"given":"Douglas Kazutoshi","family":"Sato","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HC-FMUSP), S\u00e3o Paulo, Brazil\/ Instituto do C\u00e9rebro do Rio Grande do Sul (InsCer), Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"bibr1-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000163"},{"key":"bibr2-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000101"},{"key":"bibr3-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-310206"},{"key":"bibr4-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0718-0"},{"key":"bibr5-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315998"},{"key":"bibr6-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1144-2"},{"key":"bibr7-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"bibr8-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001367"},{"key":"bibr9-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00393-2"},{"key":"bibr10-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000257"},{"key":"bibr11-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515591071"},{"key":"bibr12-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0717-1"},{"key":"bibr13-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000040"},{"key":"bibr14-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2016.09.007"},{"key":"bibr15-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8615-8"},{"key":"bibr16-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2016.02.004"},{"key":"bibr17-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.12.004"},{"key":"bibr18-1352458518811597","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318228c0b1"}],"container-title":["Multiple 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