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In 1896, Retzius named a structure in the posterior medulla oblongata as the area postrema. The work of Borison in the middle of the 20th century led to the elucidation of its function as a \u201cvomiting center.\u201d The historical medical literature is filled with excellent examples that could be described as \u201carea postrema syndrome.\u201d While severe and bilateral optic neuritis and transverse myelitis still constitute the classic components of neuromyelitis optica spectrum disorder (NMOSD), intractable vomiting and hiccups due to area postrema involvement is now recognized as essentially pathognomonic, indeed a shiny pearl in neuroimmunology and demyelinating diseases.<\/jats:p>","DOI":"10.1177\/1352458518813105","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T04:59:38Z","timestamp":1542862778000},"page":"325-329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Area postrema syndrome: A short history of a pearl in demyelinating diseases"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0676-6675","authenticated-orcid":false,"given":"Carlos R","family":"Camara-Lemarroy","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada\/ The Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada\/ Department of Clinical Neurosciences, Cumming School of Medicine, MS Clinic and Foothills Medical Centre, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie M","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,22]]},"reference":[{"key":"bibr1-1352458518813105","unstructured":"Retzius G. Das Menschentlirn. Studien in der makroskopischen Morphologie, vol. 1. Stockholm: P. A. Norstedt & Sner, 1896, pp. 42\u201343."},{"key":"bibr2-1352458518813105","unstructured":"Cammermeyer J. The area postrema. A contribution to its normal and pathological anatomy, especially in haemochromatosis. Oslo: J. Dybwad, 1945, p. 37."},{"key":"bibr3-1352458518813105","first-page":"1","volume":"3","author":"Giannuzzi G.","year":"1865","journal-title":"f d med Wissensch"},{"key":"bibr4-1352458518813105","doi-asserted-by":"publisher","DOI":"10.1007\/BF01881928"},{"key":"bibr5-1352458518813105","first-page":"1","volume":"3","author":"Openchowski T.","year":"1889","journal-title":"Zentralbl F 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