{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:15:57Z","timestamp":1792134957278,"version":"4.4.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Exc 257"],"award-info":[{"award-number":["Exc 257"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Spinal cord (SC) affection is a hallmark symptom of neuromyelitis optica spectrum disorders (NMOSD). Patients with aquaporin-4 (AQP4-IgG+) or myelin oligodendrocyte glycoprotein (MOG-IgG+) antibody seropositivity show this overlapping clinical phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Quantitative comparison of SC lesions and atrophy in AQP4-IgG+ and MOG-IgG+ NMOSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>AQP4-IgG+ ( n\u2009=\u200938), MOG-IgG+ ( n\u2009=\u200915) NMOSD patients and healthy controls (HC, n\u2009=\u200924) were analysed for SC lesion (prevalence, length, location), atrophy as mean upper cervical cord area (MUCCA), Expanded Disability Status Scale (EDSS), timed 25-foot walk speed (T25FWS) and 9-hole peg test (9HPT) measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 92% (35\/38) of AQP4-IgG+ and 53% (8\/15) of MOG-IgG+ patients had myelitis attacks (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20096.47, p\u2009=\u20090.011). 65.8%\/26.7% of AQP4-\/MOG-IgG+ patients had chronic SC lesions (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20095.16, p\u2009=\u20090.023), with similar proportions in cervical, upper thoracic and lower thoracic cord, and no length differences. MUCCA was decreased in AQP4-IgG+ ( t\u2009=\u2009\u20132.27, p\u2009=\u20090.028), but not MOG-IgG+ patients ( t\u2009=\u20090.58, p\u2009=\u20090.57) compared to HC. MUCCA associated with myelitis attacks (rho\u2009=\u2009\u20130.33, p\u2009=\u20090.016), EDSS (rho\u2009=\u2009\u20130.31, p\u2009=\u20090.030), pyramidal functional score (rho\u2009=\u2009\u20130.42, p\u2009=\u20090.003), T25FWS ( r\u2009=\u20090.43, p\u2009=\u20090.010) and 9HPT Z-score ( r\u2009=\u20090.32, p\u2009=\u20090.037), regardless of antibody status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>AQP4-IgG+ patients had more myelitis attacks, SC lesions and SC atrophy was more pronounced than in MOG-IgG+ patients. MUCCA is associated with clinical myelitis attacks and disability in all NMOSD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458518815596","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T09:57:17Z","timestamp":1543226237000},"page":"1926-1936","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":66,"title":["Spinal cord lesions and atrophy in NMOSD with AQP4-IgG and MOG-IgG associated autoimmunity"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8280-9513","authenticated-orcid":false,"given":"Claudia","family":"Chien","sequence":"first","affiliation":[{"name":"NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Scheel","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany\/Department of Neuroradiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Schmitz-H\u00fcbsch","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Borisow","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany\/Department of Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemens","family":"Ruprecht","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, 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