{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:26:45Z","timestamp":1777937205607,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Daclizumab is a monoclonal antibody that binds the high-affinity interleukin-2 receptor and was approved for the treatment of relapsing multiple sclerosis. Due to severe inflammatory brain disorders, the approval was suspended in March 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective and Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study summarizes clinical, laboratory, radiological, and histological findings of seven patients who developed meningo-\/encephalitis after daclizumab therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients presented with encephalitis and\/or meningitis and suffered from systemic symptoms such as fever (5\/7), exanthema (5\/7), or gastrointestinal symptoms (4\/7). Secondary autoimmune diseases developed. Blood analysis revealed an increase in eosinophils (5\/7). Six patients fulfilled the diagnostic criteria for a drug reaction with eosinophilia and systemic symptoms (DRESS). Magnetic resonance imaging (MRI) showed multiple contrast-enhancing lesions, and enhancement of the ependyma (6\/7), meninges (5\/7), cranial or spinal nerves (2\/7), and a vasculitic pattern (3\/7). Histology revealed a pronounced inflammatory infiltrate consisting of lymphocytes, plasma cells and eosinophils, and densely infiltrated vessels. Most patients showed an insufficient therapeutic response and a high disability at last follow-up (median Expanded Disability Status Scale (EDSS) 8). Two patients died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Meningoencephalitis and DRESS may occur with daclizumab therapy. This potential lethal side effect is characterized by a dysregulated immune response. Our findings underline the importance of postmarketing drug surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458518819098","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T09:52:02Z","timestamp":1547805122000},"page":"1618-1632","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Severe meningo-\/encephalitis after daclizumab therapy for multiple sclerosis"],"prefix":"10.1177","volume":"25","author":[{"given":"Lidia","family":"Stork","sequence":"first","affiliation":[{"name":"Institute of Neuropathology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Br\u00fcck","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"von Gottberg","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Pulkowski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Imland Hospital, Rendsburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Kirsten","sequence":"additional","affiliation":[{"name":"Department of Neurology, Imland Hospital, Rendsburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Glatzel","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Hospital Hamburg Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Rauer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Scheibe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Radbruch","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckhard","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Marienkrankenhaus, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klarissa 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