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In particular, an arterial inflammatory process, secondary to cytokine release, could potentially lead to intimal thickening, luminal irregularities, stenosis, and ultimately occlusion. Occurrence of an unexpected serious adverse event, in our case, multiple cervical artery dissections, especially in a close time window after drug administration, questions a potential causal relationship with the drug or a simple coincidence.<\/jats:p>","DOI":"10.1177\/1352458519828663","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T09:49:47Z","timestamp":1557395387000},"page":"381-383","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Spontaneous multiple cervical artery dissections after alemtuzumab"],"prefix":"10.1177","volume":"26","author":[{"given":"Fran\u00e7oise","family":"Durand-Dubief","sequence":"first","affiliation":[{"name":"Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation\u2014H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France\/ CREATIS, UMR5520 & U1044 INSERM, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Marignier","sequence":"additional","affiliation":[{"name":"Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation\u2014H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France\/Lyon Neuroscience Research Center, U1028 INSERM, UMR5292 CNRS, Lyon, France\/Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Berthezene","sequence":"additional","affiliation":[{"name":"CREATIS, UMR5520 & U1044 INSERM, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France\/Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France\/Service de Neuroradiologie diagnostique, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Cottin","sequence":"additional","affiliation":[{"name":"Department of Pharmacotoxicology, Lyon University Hospital, Hospices Civils de Lyon, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Nighoghossian","sequence":"additional","affiliation":[{"name":"CREATIS, UMR5520 & U1044 INSERM, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France\/Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France\/Service de Neurologie Vasculaire, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7337-7122","authenticated-orcid":false,"given":"Sandra","family":"Vukusic","sequence":"additional","affiliation":[{"name":"Service de neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et neuro-inflammation\u2014H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France\/Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France\/Lyon Neuroscience Research Center, Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, INSERM 1028 and CNRS UMR 5292, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"bibr1-1352458519828663","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61769-3"},{"key":"bibr2-1352458519828663","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61768-1"},{"key":"bibr3-1352458519828663","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000228"},{"key":"bibr4-1352458519828663","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005417"},{"key":"bibr5-1352458519828663","unstructured":"FDA Drug Safety Communication. FDA warns about rare but serious risks of stroke and blood vessel wall tears with multiple sclerosis drug Lemtrada (alemtuzumab), https:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm624247.htm (accessed 29 November 2018)."},{"key":"bibr6-1352458519828663","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00009-5"},{"key":"bibr7-1352458519828663","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005049"},{"key":"bibr8-1352458519828663","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.599548"},{"key":"bibr9-1352458519828663","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0107"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458519828663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458519828663","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458519828663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:58:33Z","timestamp":1777694313000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458519828663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1177\/1352458519828663"],"URL":"https:\/\/doi.org\/10.1177\/1352458519828663","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,9]]}}}