{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:29:28Z","timestamp":1782959368081,"version":"3.54.5"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To determine the difference in autonomic symptom burden measured with the Composite Autonomic System Score-31 (COMPASS-31) and presence of objective dysautonomia in people with neuromyelitis optica spectrum disorders (pwNMOSD) compared to people with multiple sclerosis (pwMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design\/Methods:<\/jats:title>\n                    <jats:p>Twenty pwNMOSD and 20 pwMS, matched for age, sex, and disease duration, were enrolled. All patients completed the COMPASS-31. The quantification of cardiovascular autonomic dysfunction (CAD) was made using the two indices of the Composite Autonomic Scoring Scale (CASS): adrenergic index (AI) and cardiovagal index (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In all pwNMOSD, COMPASS-31 was &gt;0. Sympathetic dysfunction was present in 8 (40%), parasympathetic dysfunction in 10 (50%), and orthostatic hypotension in 6 (30%) pwNMOSD. This group of patients had higher frequency and level on the pupillomotor domain of the COMPASS-31 compared to pwMS ( p\u2009=\u20090.048 and p\u2009=\u20090.006, respectively). A binary logistic regression model showed that drop in diastolic blood pressure (dBP) during tilt-table test and normal function of autonomic nervous system, defined as AI\u2009=\u20090 and CI\u2009=\u20090, were independent predictors of pwNMOSD ( p\u2009=\u20090.042 and p\u2009=\u20090.029, respectively). If CAD was present, it was significantly worse in pwNMOSD compared to pwMS ( p\u2009=\u20090.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Significant proportion of pwNMOSD experience dysautonomia, which seems to be different from dysautonomia observed in pwMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458519837703","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T08:38:19Z","timestamp":1552984699000},"page":"688-695","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Autonomic dysfunction in people with neuromyelitis optica spectrum disorders"],"prefix":"10.1177","volume":"26","author":[{"given":"Luka","family":"Crno\u0161ija","sequence":"first","affiliation":[{"name":"Referral Center for Autonomic Nervous System Disorders, Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Krbot Skori\u0107","sequence":"additional","affiliation":[{"name":"Referral Center for Autonomic Nervous System Disorders, Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia\/Faculty of Electrical Engineering and computing, University of Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Andabaka","sequence":"additional","affiliation":[{"name":"Clinic of Neurology, CCS, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamari","family":"Junakovi\u0107","sequence":"additional","affiliation":[{"name":"Referral Center for Autonomic Nervous System Disorders, Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanja","family":"Martinovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Neurology, CCS, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana","family":"Ivanovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Neurology, CCS, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160arlota","family":"Mesaro\u0161","sequence":"additional","affiliation":[{"name":"Clinic of Neurology, CCS, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Pekmezovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Drulovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Neurology, CCS, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3360-1748","authenticated-orcid":false,"given":"Mario","family":"Habek","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Zagreb, Zagreb, 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