{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:57:30Z","timestamp":1793332650725,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RG-1606-08768"],"award-info":[{"award-number":["RG-1606-08768"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS082347"],"award-info":[{"award-number":["R01NS082347"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The retinal vasculature may be altered in multiple sclerosis (MS), potentially acting as a biomarker of disease processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare retinal vascular plexus densities in people with MS (PwMS) and healthy controls (HCs), and examine correlations with visual function and global disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this cross-sectional study, 111 PwMS (201 eyes) and 50 HCs (97 eyes) underwent optical coherence tomography angiography (OCTA). Macular superficial vascular plexus (SVP) and deep vascular plexus (DVP) densities were quantified, and poor quality images were excluded according to an artifact-rating protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean SVP density was 24.1% (SD\u2009=\u20095.5) in MS eyes (26.0% (SD\u2009=\u20094.7) in non-optic neuritis (ON) eyes vs. 21.7% (SD\u2009=\u20095.5) in ON eyes, p\u2009&lt;\u20090.001), as compared to 29.2% (SD\u2009=\u20093.3) in HC eyes ( p\u2009&lt;\u20090.001 for all MS eyes and multiple sclerosis optic neuritis (MSON) eyes vs. HC eyes, p\u2009=\u20090.03 for MS non-ON eyes vs. HC eyes). DVP density did not differ between groups. In PwMS, lower SVP density was associated with higher levels of disability (expanded disability status scale (EDSS): R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.26, p\u2009=\u20090.004; multiple sclerosis functional composite (MSFC): R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.27, p\u2009=\u20090.03) and lower letter acuity scores (100% contrast: R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.29; 2.5% contrast: R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.40; 1.25% contrast: R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.31; p\u2009&lt;\u20090.001 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Retinal SVP density measured by OCTA is reduced across MS eyes, and correlates with visual function, EDSS, and MSFC scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458519845116","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T05:16:16Z","timestamp":1557983776000},"page":"815-828","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":103,"title":["Alterations in the retinal vasculature occur in multiple sclerosis and exhibit novel correlations with disability and visual function measures"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7880-8948","authenticated-orcid":false,"given":"Olwen C","family":"Murphy","sequence":"first","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohemaa","family":"Kwakyi","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Iftikhar","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidra","family":"Zafar","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Lambe","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8812-1637","authenticated-orcid":false,"given":"Elias S","family":"Sotirchos","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Gonzalez-Caldito","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Ogbuokiri","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-233X","authenticated-orcid":false,"given":"Angeliki","family":"Filippatou","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter","family":"Risher","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norah","family":"Cowley","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Feldman","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Fioravante","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot M","family":"Frohman","sequence":"additional","affiliation":[{"name":"Department of Neurology and Ophthalmology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa C","family":"Frohman","sequence":"additional","affiliation":[{"name":"Department of Neurology and Ophthalmology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J","family":"Balcer","sequence":"additional","affiliation":[{"name":"Langone Medical Center, Department of Neurology, New York University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry L","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roomasa","family":"Channa","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, School of Medicine, The Johns Hopkins 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