{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:27:20Z","timestamp":1777937240557,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to evaluate magnetic resonance imaging (MRI) previously used criteria (Matthews\u2019s criteria, MC) for differentiating multiple sclerosis (MS) from neuromyelitis optica spectrum disorders (NMOSD) in Caucasian and non-Caucasian populations (Argentina, Brazil and Venezuela) with positive (P-NMOSD), negative (N-NMOSD), and unknown (U-NMOSD) aquaporin-4 antibody serostatus at disease onset and to assess the added diagnostic value of spinal cord MRI in these populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We reviewed medical records, and MRIs were assessed by two blinded evaluators and were scored using MC. Short-segment transverse myelitis (STM) was added as a new criterion. MC sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We included 282 patients (MS\u2009=\u2009188 and NMOSD\u2009=\u200994). MC applied to the entire cohort showed 97.8% sensitivity, 82.9% specificity, 92.0% PPV, and 95.1% NPV for differentiating MS from NMOSD. A subanalysis applied only to non-Caucasian (MS\u2009=\u200989 and NMOSD\u2009=\u200947) showed 100% sensitivity, 80.8% specificity, 90.8% PPV, and 100% NPV. Similar sensitivity, specificity, PPV, and NPV of MC for MS versus P-NMOSD ( n\u2009=\u200955), N-NMOSD ( n\u2009=\u200928), and U-NMOSD ( n\u2009=\u200921) were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MC distinguished MS from NMOSD of all serostatus in a Latin American cohort that included non-Caucasian populations. Addition of STM to MC did not raise the accuracy significantly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458519849517","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:09:31Z","timestamp":1558696171000},"page":"945-954","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Brain and spinal MRI features distinguishing MS from different AQP4 antibody serostatus NMOSD at disease onset in a cohort of Latin American patients"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-5726","authenticated-orcid":false,"given":"Edgar","family":"Carnero Contentti","sequence":"first","affiliation":[{"name":"Neuroimmunology Unit, Department of Neuroscience, Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Daccach","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behavioral Sciences, Hospital das Cl\u00ednicas, Ribeir\u00e3o Preto Medical School, University of de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-372X","authenticated-orcid":false,"given":"Ibis","family":"Soto de Castillo","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Tkachuk","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Neurology, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amilton Antunes","family":"Barreira","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behavioral Sciences, Hospital das Cl\u00ednicas, Ribeir\u00e3o Preto Medical School, University of de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Caride","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Neuroscience, Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C","family":"Castillo","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgardo","family":"Cristiano","sequence":"additional","affiliation":[{"name":"Centro de Esclerosis M\u00faltiple de Buenos Aires (CEMBA), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"de Aquino Cruz","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behavioral Sciences, Hospital das Cl\u00ednicas, Ribeir\u00e3o Preto Medical School, University of de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Braga Di\u00e9gues Serva","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behavioral Sciences, Hospital das Cl\u00ednicas, Ribeir\u00e3o Preto Medical School, University of de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5502-4734","authenticated-orcid":false,"given":"Antonio Carlos dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behavioral Sciences, Hospital das Cl\u00ednicas, Ribeir\u00e3o Preto Medical School, University of de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossanny","family":"Labarca","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Lavigne Moreira","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behavioral Sciences, Hospital das Cl\u00ednicas, Ribeir\u00e3o Preto Medical School, University of de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo A","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Neuroscience, Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimena","family":"Miguez","sequence":"additional","affiliation":[{"name":"Centro de 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