{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:29:20Z","timestamp":1777937360258,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Brain magnetic resonance imaging (MRI) is the most effective surveillance tool for the detection of asymptomatic progressive multifocal leukoencephalopathy (PML). However, the optimal frequency for routine MRI surveillance is under-investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To understand whether, upon their first MRI appearance, PML lesions present a difference in volume when comparing patients who frequently underwent MRI surveillance (3\/4\u2009months) with those who were assessed at longer intervals (6\/12\u2009months) and to understand the impact of the volume of lesions on clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The data of patients included in the Italian PML cohort were retrospectively analysed. Patients who had all the pre-diagnostic MRI scans available ( n\u2009=\u200937) were included. The volume of PML lesion was calculated by manually outlining the PML lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with patients who underwent MRI examination at least every 4\u2009months, patients who were assessed less frequently had a lesion of significantly higher volume (median: 2567 (883\u20133583) vs. 664\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      (392\u2013963) p\u2009=\u20090.006) and suffered a higher rate of disability (median: 2.25 expanded disability status scale points (\u20132.5 to 8) vs. 0.5 (\u20131 to 2.5) p\u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The positive clinical outcome of patients undergoing frequent MRI surveillance and the small volume of the PML lesion upon first appearance justify a frequent surveillance using MRI in patients at high risk of PML.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458519854162","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T05:47:58Z","timestamp":1559195278000},"page":"1227-1236","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Should frequent MRI monitoring be performed in natalizumab-treated MS patients? A contribution to a recent debate"],"prefix":"10.1177","volume":"26","author":[{"given":"Cristina","family":"Scarpazza","sequence":"first","affiliation":[{"name":"Regional Multiple Sclerosis Center, ASST Spedali Civili di Brescia, Montichiari, Italy; Department of General Psychology, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Signori","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirco","family":"Cosottini","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Surgical and Medical Technologies, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6892-104X","authenticated-orcid":false,"given":"Maria Pia","family":"Sormani","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Gerevini","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruggero","family":"Capra","sequence":"additional","affiliation":[{"name":"Regional Multiple Sclerosis Center, ASST Spedali Civili di Brescia, Via Ciotti, 154, Montichiari 25018, Brescia, 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