{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:15:35Z","timestamp":1789193735110,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Wilhelm Uhthoff, known for his contributions to both neurology and neuro-ophthalmology, was a German ophthalmologist who specialized in neurologic disorders. The eponym \u201cUhthoff\u2019s phenomenon\u201d was first used to describe the reversible, transient blurring of vision in patients with multiple sclerosis during exercise. Subsequently, it was discovered that this neurologic sign not only was triggered by physical exertion but also by other homeostatic disruptions such as hot baths, menstruation, and high external temperatures. Here, we take a look at the life and career of Wilhelm Uhthoff and discuss the basis behind this phenomenon.<\/jats:p>","DOI":"10.1177\/1352458519881950","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T10:45:30Z","timestamp":1571309130000},"page":"1790-1796","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Wilhelm Uhthoff and Uhthoff\u2019s phenomenon"],"prefix":"10.1177","volume":"26","author":[{"given":"Aarushi","family":"Jain","sequence":"first","affiliation":[{"name":"Boston University, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Rosso","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Disease, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8350-8234","authenticated-orcid":false,"given":"Jonathan D","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA\/Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"bibr1-1352458519881950","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-199506000-00002"},{"issue":"3","key":"bibr2-1352458519881950","first-page":"90","volume":"15","author":"Stutzer P","year":"2008","journal-title":"Int MS J"},{"key":"bibr3-1352458519881950","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7399-3"},{"key":"bibr4-1352458519881950","unstructured":"Schnurr EM. 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