{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:28:40Z","timestamp":1777937320707,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003669","name":"Korean Centers for Disease Control and Prevention","doi-asserted-by":"crossref","award":["2017E6300200"],"award-info":[{"award-number":["2017E6300200"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"national research foundation of korea","doi-asserted-by":"publisher","award":["NRF2017R1A2B4006975"],"award-info":[{"award-number":["NRF2017R1A2B4006975"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neuromyelitis optica spectrum disorder (NMOSD) targets astrocytes and elevates the levels of astrocyte-injury markers during attacks. FAM19A5, involved in reactive gliosis, is secreted by reactive astrocytes following central nervous system (CNS) damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the significance of serum FAM19A5 in patients with NMOSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We collected clinical data and sera of 199 patients from 11 hospitals over 21\u2009months. FAM19A5 levels were compared among three groups: NMOSD with positive anti-aquaporin-4 antibody (NMOSD-AQP4), other CNS demyelinating disease, and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The median serum FAM19A5 level was higher in the NMOSD-AQP4 (4.90\u2009ng\/mL (3.95, 5.79)) than in the other CNS demyelinating (2.35\u2009ng\/mL (1.83, 4.07), p\u2009&lt;\u20090.001) or healthy control (1.02\u2009ng\/mL (0.92, 1.14), p\u2009&lt;\u20090.001) groups. There were significant differences in the median serum FAM19A5 levels between the attack and remission periods (5.89\u2009ng\/mL (5.18, 6.98); 4.40\u2009ng\/mL (2.72, 5.13), p\u2009&lt;\u20090.001) in the NMOSD-AQP4 group. Sampling during an attack ( p\u2009&lt;\u20090.001) and number of past attacks ( p\u2009=\u20090.010) were independently associated with increased serum FAM19A5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum FAM19A5 was higher in patients with NMOSD-AQP4 and correlated with clinical characteristics. Thus, serum FAM19A5 may be a novel clinical biomarker for NMOSD-AQP4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458519885489","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T06:03:16Z","timestamp":1572847396000},"page":"1700-1707","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum FAM19A5 in neuromyelitis optica spectrum disorders: Can it be a new biomarker representing clinical status?"],"prefix":"10.1177","volume":"26","author":[{"given":"Hye Lim","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology, Korea University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung Youl","family":"Seok","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Wook","family":"Ryu","sequence":"additional","affiliation":[{"name":"Neuracle Science Co. Ltd., Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Bee","family":"Cho","sequence":"additional","affiliation":[{"name":"Neuracle Science Co. Ltd., Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Neuracle Science Co. Ltd., Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea\/Neuroscience Center, Samsung Medical Center, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Hong","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea\/Neuroscience Center, Samsung Medical Center, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Myoung","family":"Seok","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soonchunhyang University Cheonan Hospital, Cheonan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa-Yoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Cheju National University, Cheju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oh-Hyun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Eulji University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chungbuk National University College of Medicine, Cheongju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeeyoung","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Konkuk University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Hee","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chungnam National University College of Medicine, Daejeon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So-Young","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kosin University College of Medicine, Busan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong-Yang","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inje University College of Medicine, Ilsan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Young","family":"Seong","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences, Korea University, Seoul, South 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