{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:28:38Z","timestamp":1777937318488,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RG-1501-03141"],"award-info":[{"award-number":["RG-1501-03141"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Magnetic resonance imaging (MRI) studies of multiple sclerosis\u2013related fatigue had limited reproducibility. Temporal fatigue fluctuations have not been considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate whether a novel group allocation that reflects temporal dynamics of fatigue improves our ability to detect fatigue-associated structural brain abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patient stratification based on biennial fatigue assessments: sustained fatigue (SF, n\u2009=\u200929, fatigued at the latest \u2a7e2 assessments), one time-point fatigue (1F, n\u2009=\u200915, fatigued at the latest, but non-fatigued at the penultimate assessment), reversible fatigue (RF, n\u2009=\u200931, non-fatigued at the latest assessment, but reported fatigue previously), and never fatigued (NF, n\u2009=\u200954). Brain parenchymal fraction (BPF) and T2 lesion volume (T2LV) were compared between these groups and were derived using a conventional, single time-point fatigued versus non-fatigued stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The SF versus NF stratification yielded improved power. SF ( p\u2009=\u20090.005) and RF ( p\u2009=\u20090.043) showed significantly higher T2LV than NF. T2LV showed no significant differences in SF versus 1F, SF versus RF, or 1F versus RF. Fatigued versus non-fatigued patients showed significantly higher T2LV ( p\u2009=\u20090.030). We found no significant differences in BPF between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Taking into account temporal fatigue dynamics increases the statistical power with respect to T2LV and may improve characterization of brain pathological correlates of MS-related fatigue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458519898112","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T05:23:52Z","timestamp":1579757032000},"page":"725-734","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["A novel classification of fatigue in multiple sclerosis based on longitudinal assessments"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0268-6977","authenticated-orcid":false,"given":"Miklos","family":"Palotai","sequence":"first","affiliation":[{"name":"Center for Neurological Imaging, Department of Radiology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Cavallari","sequence":"additional","affiliation":[{"name":"Center for Neurological Imaging, Department of Radiology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian C","family":"Healy","sequence":"additional","affiliation":[{"name":"Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA\/Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles RG","family":"Guttmann","sequence":"additional","affiliation":[{"name":"Center for Neurological Imaging, Department of Radiology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"bibr1-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.08.007"},{"key":"bibr2-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519876032"},{"key":"bibr3-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1007\/s004150070148"},{"key":"bibr4-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.07.004"},{"key":"bibr5-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508098373"},{"key":"bibr6-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519869185"},{"key":"bibr7-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.11.046"},{"key":"bibr8-1352458519898112","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00155"},{"key":"bibr9-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51110-2"},{"key":"bibr10-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1151"},{"key":"bibr11-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516628331"},{"key":"bibr12-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1007\/s004150200060"},{"key":"bibr13-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513493684"},{"key":"bibr14-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050382"},{"key":"bibr15-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.2.201"},{"key":"bibr16-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00251-2"},{"key":"bibr17-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517711273"},{"key":"bibr18-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.121129"},{"key":"bibr19-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1037\/a0027890"},{"key":"bibr20-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1191\/1352458502ms839oa"},{"key":"bibr21-1352458519898112","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12491"},{"key":"bibr22-1352458519898112","first-page":"81","volume":"2004","author":"Pohl 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