{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:20:27Z","timestamp":1792653627690,"version":"4.5.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A paradoxical discrepancy between severe peripapillary retinal nerve fiber layer (pRNFL) atrophy and good visual outcome had been reported in patients with myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-associated optic neuritis (ON). However, only visual acuity (VA) was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To study visual field (VF) outcomes of patients with MOG-IgG-associated ON and evaluate the correlation between functional eye outcome and retinal structural changes assessed by optical coherence tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The records of 32 patients with MOG-IgG-associated ON who underwent ophthalmological examination at least 12\u2009months after ON onset were reviewed. Degree of VF disability was determined by mean deviation (MD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At final assessment (median, 35\u2009months), 4.2% of 48 affected eyes (AE) had VA\u2009\u2a7d\u20090.1, 40% had abnormal MD, and among AE with final VA\u2009\u2a7e\u20091.0, 31% had mild to moderate damage. Thinning of the inner retinal layers was significantly correlated with MD impairment. Analysis demonstrated a threshold of pRNFL thickness (50\u2009\u00b5m), below which MD was significantly worse (mean, \u22122.27\u2009dB vs \u221217.72\u2009dB; p\u2009=\u20090.0003). ON relapse was significantly associated with poor visual outcome assessed by MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Functional impairment measured with VF is not rare, and MD assessment better reflects actual structural damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458520937281","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T11:12:07Z","timestamp":1594120327000},"page":"855-863","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Visual field loss and structure\u2013function relationships in optic neuritis associated with myelin oligodendrocyte glycoprotein antibody"],"prefix":"10.1177","volume":"27","author":[{"given":"Romain","family":"Deschamps","sequence":"first","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Philibert","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France\/Department of Neuro-Ophthalmology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Lamirel","sequence":"additional","affiliation":[{"name":"Department of Neuro-Ophthalmology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Lambert","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany\/UMR1153 ECSTRRA Team INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Vasseur","sequence":"additional","affiliation":[{"name":"Clinical Research Department, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Gueguen","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bensa","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin","family":"Lecler","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Marignier","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospices civils de Lyon, H\u00f4pital neurologique Pierre Wertheimer, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-8905","authenticated-orcid":false,"given":"Catherine","family":"Vignal","sequence":"additional","affiliation":[{"name":"Department of Neuro-Ophthalmology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gout","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"bibr1-1352458520937281","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005560"},{"key":"bibr2-1352458520937281","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.07.020"},{"key":"bibr3-1352458520937281","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx276"},{"key":"bibr4-1352458520937281","first-page":"1381","volume":"90","author":"Senanayake B","year":"2019","journal-title":"J Neurol Neurosurg 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