{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T21:35:42Z","timestamp":1787175342725,"version":"build-2736575974"},"reference-count":35,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","award":["Melbourne Research Scholarship"],"award-info":[{"award-number":["Melbourne Research Scholarship"]}],"id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003000","name":"Stichting MS Research","doi-asserted-by":"publisher","award":["08-650, 13-820, 14-358e"],"award-info":[{"award-number":["08-650, 13-820, 14-358e"]}],"id":[{"id":"10.13039\/501100003000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Network abnormalities could help explain physical disability in multiple sclerosis (MS), which remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study investigates functional network efficiency changes in the sensorimotor system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included 222 MS patients, divided into low disability (LD, Expanded Disability Status Scale (EDSS) \u2a7d3.5, n\u2009=\u2009185) and high disability (HD, EDSS \u2a7e6, n\u2009=\u200937), and 82 healthy controls (HC). Functional connectivity was assessed between 23 sensorimotor regions. Measures of efficiency were computed and compared between groups using general linear models corrected for age and sex. Binary logistic regression models related disability status to local functional network efficiency (LE), brain volumes and demographics. Functional connectivity patterns of regions important for disability were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      HD patients demonstrated significantly higher LE of the left primary somatosensory cortex (S1) and right pallidum compared to LD and HC, and left premotor cortex compared to HC only. The logistic regression model for disability ( R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.38) included age, deep grey matter volume and left S1 LE. S1 functional connectivity was increased with prefrontal and secondary sensory areas in HD patients, compared to LD and HC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Clinical disability in MS associates with functional sensorimotor increases in efficiency and connectivity, centred around S1, independent of structural damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458520966292","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T23:50:26Z","timestamp":1603842626000},"page":"1364-1373","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Increased functional sensorimotor network efficiency relates to disability in multiple sclerosis"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8995-9899","authenticated-orcid":false,"given":"Myrte","family":"Strik","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands\/Department of Radiology and Medicine, The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3076-2682","authenticated-orcid":false,"given":"Declan T","family":"Chard","sequence":"additional","affiliation":[{"name":"NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK\/National Institute for Health Research, University College London Hospitals Biomedical Research Centre, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands\/Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand JC","family":"Eijlers","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pardini","sequence":"additional","affiliation":[{"name":"NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK\/Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa, Genoa, Italy\/Ospedale Policlinico San Martino-IRCCS, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard MJ","family":"Uitdehaag","sequence":"additional","affiliation":[{"name":"Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4685-1380","authenticated-orcid":false,"given":"Scott C","family":"Kolbe","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medicine, The University of Melbourne, Melbourne, VIC, Australia\/Department of Neurosciences, Central Clinical School, Monash University, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen JG","family":"Geurts","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-6959","authenticated-orcid":false,"given":"Menno M","family":"Schoonheim","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"bibr1-1352458520966292","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2012-053"},{"key":"bibr2-1352458520966292","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001756"},{"key":"bibr3-1352458520966292","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018172311"},{"key":"bibr4-1352458520966292","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101426"},{"key":"bibr5-1352458520966292","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy088"},{"key":"bibr6-1352458520966292","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511435930"},{"key":"bibr7-1352458520966292","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq058"},{"key":"bibr8-1352458520966292","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512460416"},{"issue":"5","key":"bibr9-1352458520966292","first-page":"328","volume":"128","author":"Dogonowski 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