{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:00:52Z","timestamp":1788206452447,"version":"build-2803163510"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the effect of continuous positive airway pressure (CPAP) treatment on the Fatigue Severity Scale (FSS, preplanned primary outcome), another fatigue measure, sleep quality, somnolence, pain, disability, and quality of life in multiple sclerosis (MS) patients with obstructive sleep apnea-hypopnea (OSAH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a randomized, double-blind trial (NCT01746342), MS patients with fatigue, poor subjective sleep quality, and OSAH (apnea-hypopnea index of\u2009\u2a7e\u200915 events per hour\/sleep), but without severe OSAH (apnea-hypopnea index\u2009&gt;\u200930, and 4% oxygen desaturation index\u2009&gt;\u200915 events\/hour or severe somnolence), were randomized to fixed CPAP or sham CPAP for 6\u2009months. Outcome assessments were performed at 3 and 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 49 randomized patients, 34 completed the protocol. Among completers, FSS did not improve with CPAP compared to sham at 6\u2009months. FSS tended to improve ( p\u2009=\u20090.09), and sleepiness (Epworth Sleepiness Scale) improved significantly ( p\u2009=\u20090.03) at 3\u2009months with CPAP compared to sham, but there were no other improvements with CPAP at either study evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In non-severe OSAH patients, CPAP did not significantly improve the primary outcome of FSS change at 6\u2009months. In secondary analyses, we found a trend to improved FSS, and a significant reduction in somnolence with CPAP at 3\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585211010390","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T07:20:42Z","timestamp":1619162442000},"page":"82-92","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of continuous positive airway pressure treatment of obstructive sleep apnea-hypopnea in multiple sclerosis: A randomized, double-blind, placebo-controlled trial (SAMS-PAP study)"],"prefix":"10.1177","volume":"28","author":[{"given":"Sulaiman","family":"Khadadah","sequence":"first","affiliation":[{"name":"Respiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R John","family":"Kimoff","sequence":"additional","affiliation":[{"name":"Respiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Duquette","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Jobin","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Department of Medicine, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Lapierre","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema T","family":"Johara","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Roger","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Bar-Or","sequence":"additional","affiliation":[{"name":"Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Kaminska","sequence":"additional","affiliation":[{"name":"Respiratory Division and Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria A","family":"Trojan","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"bibr1-13524585211010390","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2004.00257.x"},{"key":"bibr2-13524585211010390","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.4044"},{"key":"bibr3-13524585211010390","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507077175"},{"key":"bibr4-13524585211010390","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.07.005"},{"key":"bibr5-13524585211010390","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00740"},{"key":"bibr6-13524585211010390","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"bibr7-13524585211010390","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.12.013"},{"key":"bibr8-13524585211010390","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511432328"},{"key":"bibr9-13524585211010390","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512455958"},{"key":"bibr10-13524585211010390","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510393772"},{"key":"bibr11-13524585211010390","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3442"},{"key":"bibr12-13524585211010390","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.12.008"},{"key":"bibr13-13524585211010390","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.05.018"},{"key":"bibr14-13524585211010390","first-page":"286581","volume":"2013","author":"Kallweit 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