{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:32:25Z","timestamp":1790652745732,"version":"4.1.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Optic neuritis (ON) is often the presenting symptom in inflammatory central nervous system demyelinating disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare the frequency and pattern of optic chiasm involvement in patients with aquaporin-4-immunoglobulin G (AQP4-IgG)-associated ON to patients with myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-associated ON.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective review of all patients evaluated at Mayo Clinic, Stanford University and Ramathibodi Hospital who were found to have: (1) ON, (2) either MOG-IgG or AQP4-IgG by cell-based assay, and (3) magnetic resonance imaging (MRI) at the time of ON. MRI was reviewed for contrast enhancement of the optic chiasm and the pattern of involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One hundred and fifty-four patients (74 AQP4-IgG and 80 MOG-IgG) were included. Among patients with AQP4-IgG-ON, 20% had chiasmal involvement, compared with 16% of patients with MOG-IgG-ON ( p = 0.66). In patients with chiasmal involvement, longitudinally extensive optic nerve enhancement (from orbit extending to chiasm) was identified in 54% of MOG-IgG-ON patients, compared with 7% of AQP4-IgG-ON patients ( p = 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Chiasmal involvement of MOG-IgG-ON and AQP4-IgG-ON occur at more similar frequencies than previously reported. Furthermore, MOG-IgG-ON chiasmal involvement is more likely to be part of a longitudinally extensive optic nerve lesion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585211011450","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T04:12:46Z","timestamp":1620792766000},"page":"149-153","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Optic chiasm involvement in AQP-4 antibody\u2013positive NMO and MOG antibody\u2013associated disorder"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8419-8728","authenticated-orcid":false,"given":"Deena","family":"Tajfirouz","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanyatuth","family":"Padungkiatsagul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand\/Department of Ophthalmology, Stanford University, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Beres","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Stanford University, Palo Alto, CA, USA\/Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E","family":"Moss","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Stanford University, Palo Alto, CA, USA\/Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Pittock","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA\/Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA\/Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-2910","authenticated-orcid":false,"given":"Eoin","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA\/Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA\/Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kunchok","sequence":"additional","affiliation":[{"name":"Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailee","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA\/Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Tariq","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA\/Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA\/Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"bibr1-13524585211011450","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1144-2"},{"key":"bibr2-13524585211011450","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005560"},{"key":"bibr3-13524585211011450","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx276"},{"key":"bibr4-13524585211011450","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.07.020"},{"key":"bibr5-13524585211011450","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-1014-z"},{"key":"bibr6-13524585211011450","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-310206"},{"key":"bibr7-13524585211011450","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515593406"},{"key":"bibr8-13524585211011450","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2018184002"},{"key":"bibr9-13524585211011450","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-311177"},{"key":"bibr10-13524585211011450","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.04.042"}],"container-title":["Multiple Sclerosis 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