{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:53:35Z","timestamp":1792616015773,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Leptomeningeal enhancement (LME) is a key feature of Susac syndrome (SuS) but is only occasionally depicted on post-contrast T1-weighted images (T1-WI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>As post-contrast fluid-attenuated inversion recovery (FLAIR) may be more sensitive, our aim was to assess LME in SuS on this sequence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>From 2010 to 2020, 20 patients with definite SuS diagnosis were retrospectively enrolled in this multicentre study. Two radiologists independently assessed the number of LME on post-contrast FLAIR and T1-WI acquisitions performed before any treatment. A chi-square test was used to compare both sequences and the interrater agreement was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirty-five magnetic resonance imagings (MRIs) were performed before treatment, including 19 post-contrast FLAIR images in 17 patients and 25 post-contrast T1-WI in 19 patients. In terms of patients, LME was observed on all post-contrast FLAIR, contrary to post-contrast T1-WI (17\/17 (100%) vs. 15\/19 (79%), p\u2009&lt;\u20090.05). In terms of sequences, LME was observed on all post-contrast FLAIR, contrary to post-contrast T1-WI (19\/19 (100%) vs. 16\/25 (64%), p\u2009&lt;\u20090.005). LME was disseminated at both supratentorial (19\/19) and infratentorial (18\/19) levels on post-contrast FLAIR, contrary to post-contrast T1-WI (3\/25 and 9\/25, respectively). Interrater agreement was excellent for post-contrast FLAIR (\u03ba\u2009=\u20090.95) but only moderate for post-contrast T1-WI (\u03ba\u2009=\u20090.61).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>LME was always observed and easily visible on post-contrast FLAIR images prior to SuS treatment. In association with other MRI features, it is highly indicative of SuS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585211012349","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T08:38:46Z","timestamp":1620981526000},"page":"189-197","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Leptomeningeal enhancement on post-contrast FLAIR images for early diagnosis of Susac syndrome"],"prefix":"10.1177","volume":"28","author":[{"given":"Guillaume","family":"Bellanger","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Purpan, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0569-629X","authenticated-orcid":false,"given":"Damien","family":"Biotti","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Purpan, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Purpan, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Darcourt","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Purpan, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaux","family":"Roques","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Purpan, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Patsoura","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Purpan, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Savatovsky","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Obadia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Menjot de Champfleur","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Gui De Chauliac, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Charif","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Gui De Chauliac, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Labauge","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Gui De Chauliac, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-2478","authenticated-orcid":false,"given":"Francois","family":"Cotton","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital civil de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Durand Dubief","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital civil de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tourdias","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Pellegrin, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Dulau","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital de Hautepierre, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Kremer","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital de Hautepierre, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"De S\u00e8ze","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Pellegrin, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-6308","authenticated-orcid":false,"given":"Jonathan","family":"Ciron","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Purpan, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Varenne","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, H\u00f4pital Purpan, Toulouse, 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