{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:32:29Z","timestamp":1777937549271,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Decreased motion perception has been suggested as a marker for visual pathway demyelination in optic neuritis (ON) and\/or multiple sclerosis (MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To examine the influence of neuro-axonal damage on motion perception in MS and neuromyelitis optica spectrum disorders (NMOSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analysed motion perception with numbers-from-motion (NFM), visual acuity, (multifocal (mf)) VEP, optical coherence tomography in patients with MS ( n = 38, confirmatory cohort n = 43), NMOSD ( n = 13) and healthy controls ( n = 33).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>NFM was lower compared with controls in MS ( B = \u221212.37, p &lt; 0.001) and NMOSD ( B = \u221234.5, p &lt; 0.001). NFM was lower in ON than in non-ON eyes ( B = \u221230.95, p = 0.041) in NMOSD, but not MS. In MS and NMOSD, lower NFM was associated with worse visual acuity ( B = \u2212139.4, p &lt; 0.001\/ B = \u221277.2, p &lt; 0.001) and low contrast letter acuity ( B = 0.99, p = 0.002\/ B = 1.6, p &lt; 0.001), thinner peripapillary retinal nerve fibre layer ( B = 1.0, p &lt; 0.001\/ B = 0.92, p = 0.016) and ganglion cell\/inner plexiform layer ( B = 64.8, p &lt; 0.001\/ B = 79.5, p = 0.006), but not with VEP P100 latencies. In the confirmatory MS cohort, lower NFM was associated with thinner retinal nerve fibre layer ( B = 1.351, p &lt; 0.001) and increased mfVEP P100 latencies ( B = \u22121.159, p &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Structural neuro-axonal visual pathway damage is an important driver of motion perception impairment in MS and NMOSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585211032801","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T09:05:48Z","timestamp":1628672748000},"page":"757-767","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Impaired motion perception is associated with functional and structural visual pathway damage in multiple sclerosis and neuromyelitis optica spectrum disorders"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-3825","authenticated-orcid":false,"given":"Noah","family":"Ayadi","sequence":"first","affiliation":[{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine and Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany\/NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederike C","family":"Oertel","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine and Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany\/NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany\/Department of Neurology, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-1791","authenticated-orcid":false,"given":"Susanna","family":"Asseyer","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine and Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany\/NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekka","family":"Rust","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine and Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany\/NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankelien","family":"Duchow","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine and Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany\/NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Kuchling","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine and Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany\/NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany\/ Department of Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Bellmann-Strobl","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine and Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany\/NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klemens","family":"Ruprecht","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Klistorner","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia\/ Save Sight Institute, The University of Sydney, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9768-014X","authenticated-orcid":false,"given":"Alexander U","family":"Brandt","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine and Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany\/NeuroCure Clinical Research Center, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Germany\/Department 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