{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:32:32Z","timestamp":1777937552662,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2021,10]]},"abstract":"\n Background:<\/jats:title>\n Hemophagocytic lymphohistiocytosis (HLH) is a rarely recognized hyperinflammatory condition of high death risk.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n The objective was to describe a case of HLH in a patient with multiple sclerosis (MS) treated with ocrelizumab<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Clinical observation, laboratory testing, and use of HLH-2004 criteria for HLH diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A 32-year-old Caucasian female developed HLH during ocrelizumab treatment. She met six of the eight HLH criteria including fever, splenomegaly, cytopenia, hypertriglyceridemia and hypofibrinogenemia, high serum ferritin level, and low natural killer (NK) cells.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n HLH should be considered in the differential diagnosis in MS patients displaying a fever and malaise syndrome following administration of ocrelizumab.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/1352458521993070","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T06:24:09Z","timestamp":1614925449000},"page":"1803-1805","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Hemophagocytic lymphohistiocytosis associated with ocrelizumab treatment in a patient with multiple sclerosis"],"prefix":"10.1177","volume":"27","author":[{"given":"Agnieszka","family":"Machla\u0144ska","sequence":"first","affiliation":[{"name":"Center of Neurology, Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Helbig","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Chromik","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Zapa\u0142a","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Zwiernik","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Selmaj","sequence":"additional","affiliation":[{"name":"Center of Neurology, Lodz, Poland\/ Department of Neurology, University of Warmia & Mazury Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"bibr1-1352458521993070","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1601277"},{"key":"bibr2-1352458521993070","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a032037"},{"key":"bibr3-1352458521993070","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2007.05.001"},{"key":"bibr4-1352458521993070","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.11.050"},{"key":"bibr5-1352458521993070","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S46255"},{"key":"bibr6-1352458521993070","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"bibr7-1352458521993070","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP4ZDKJ4ICOUAT"},{"key":"bibr8-1352458521993070","first-page":"101973","volume":"40","author":"Romeroa AL","year":"2020","journal-title":"MSRD"},{"key":"bibr9-1352458521993070","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000247"},{"key":"bibr10-1352458521993070","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.10.003"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458521993070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458521993070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458521993070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:08:43Z","timestamp":1777694923000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458521993070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1177\/1352458521993070"],"URL":"https:\/\/doi.org\/10.1177\/1352458521993070","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,5]]}}}