{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:33:18Z","timestamp":1777937598237,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Aquaporin-4 antibody (AQP4-Ab) Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare neuroinflammatory syndrome presenting predominantly with optic neuritis and transverse myelitis. We report a case of radiologically isolated longitudinally extensive optic neuritis in an asymptomatic 12-year-old female with positive serum AQP4-Ab, with resolution of imaging changes after immune therapy. By contrast to patients with radiologically isolated syndrome, of which some will never convert to multiple sclerosis, the pathogenicity of AQP4-Ab in the context of sub-clinical disease, supported treatment in our patient. Given the severe morbidity in AQP4-Ab NMOSD, prognostic biomarkers for disease severity are required to guide optimal therapy for patients.<\/jats:p>","DOI":"10.1177\/13524585221074947","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T05:57:14Z","timestamp":1648187834000},"page":"676-679","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Radiologically isolated aquaporin-4 antibody neuromyelitis optica spectrum disorder"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0796-9645","authenticated-orcid":false,"given":"Omar","family":"Abdel-Mannan","sequence":"first","affiliation":[{"name":"Queen Square MS Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainat","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat","family":"Bachar Zipori","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat","family":"Ben-Sira","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aviva","family":"Fattal-valevski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Hacohen","sequence":"additional","affiliation":[{"name":"Queen Square MS Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadas","family":"Meirson","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"bibr1-13524585221074947","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318296ea08"},{"key":"bibr2-13524585221074947","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13703"},{"key":"bibr3-13524585221074947","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"bibr4-13524585221074947","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz054"},{"key":"bibr5-13524585221074947","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000837"},{"key":"bibr6-13524585221074947","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000572"},{"key":"bibr7-13524585221074947","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010847"},{"key":"bibr8-13524585221074947","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000104"},{"key":"bibr9-13524585221074947","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31817-3"},{"key":"bibr10-13524585221074947","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000947"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585221074947","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585221074947","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585221074947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:08:55Z","timestamp":1777694935000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585221074947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/13524585221074947"],"URL":"https:\/\/doi.org\/10.1177\/13524585221074947","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,25]]}}}