{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:36:25Z","timestamp":1791333385908,"version":"4.3.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"EU Joint Programme-Neurodegenerative Diseases networks PreFrontAls and Genfi-Prox","award":["01ED1512"],"award-info":[{"award-number":["01ED1512"]}]},{"name":"the Jubilaeumsfonds of the Austrian National Bank","award":["14158"],"award-info":[{"award-number":["14158"]}]},{"name":"the Jubilaeumsfonds of the Austrian National Bank","award":["15918"],"award-info":[{"award-number":["15918"]}]},{"DOI":"10.13039\/100008792","name":"Novartis Pharma GmbH","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Thierry Latran Foundation"},{"name":"German Federal Ministry of Education and Research","award":["FTLDc 01GI1007A"],"award-info":[{"award-number":["FTLDc 01GI1007A"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the diagnostic and prognostic potential of serum neurofilament light chain (sNfL) in children with first acquired demyelinating syndrome (ADS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We selected 129 children with first ADS including 19 children with myelin oligodendrocyte glycoprotein (MOG)-antibody associated disease (MOGAD), 36 MOG\/AQP4-seronegative ADS, and 74 with multiple sclerosis (MS) from the BIOMARKER study cohort. All children had a complete set of clinical, radiological, laboratory data and serum for NfL measurement using a highly sensitive digital ELISA (SIMOA). A control group of 35 children with non-inflammatory neurological diseases was included. sNfL levels were compared across patient groups according to clinical, laboratory, neuroradiological features and outcome after 2\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>sNfL levels were significantly increased in MOGAD, seronegative ADS and MS compared to controls ( p-value\u2009&lt;\u20090.001), in particular in children with an acute disseminated encephalomyelitis (ADEM)-like magnetic resonance imaging (MRI) pattern ( p\u2009&lt;\u20090.001) or longitudinally extensive myelitis ( p\u2009&lt;\u20090.01). In pediatric MS, elevated sNfL levels were significantly associated with higher numbers of cerebral ( p\u2009&lt;\u20090.001) and presence of spinal ( p\u2009&lt;\u20090.05) MRI lesions at baseline and predicted a higher number of relapses ( p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>sNfL levels are significantly elevated in all three studied pediatric ADS subtypes indicating neuroaxonal injury. In pediatric MS high levels of sNfL are associated with risk factors for disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585221081090","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T03:07:10Z","timestamp":1647227230000},"page":"1553-1561","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Serum neurofilament light-chain levels in children with monophasic myelin oligodendrocyte glycoprotein-associated disease, multiple sclerosis, and other acquired demyelinating syndrome"],"prefix":"10.1177","volume":"28","author":[{"given":"Eva-Maria","family":"Wendel","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annikki","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Children\u2019s Hospital Datteln, University Witten\/Herdecke, Datteln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lampros","family":"Kousoulos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Children\u2019s Hospital Datteln, University Witten\/Herdecke, Datteln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Rauchenzauner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, Kliniken Ostallg\u00e4u-Kaufbeuren, Kaufbeuren, Germany\/Division of Pediatric Neurology, Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Schanda","sequence":"additional","affiliation":[{"name":"Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wegener-Panzer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology, Children`s Hospital Datteln, University Witten\/Herdecke, Datteln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-8324","authenticated-orcid":false,"given":"Matthias","family":"Baumann","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-1402","authenticated-orcid":false,"given":"Markus","family":"Reindl","sequence":"additional","affiliation":[{"name":"Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Ulm, Ulm, Germany; Department of Neurology, Martin Luther University Halle-Wittenberg, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Rost\u00e1sy","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Children\u2019s Hospital Datteln, University Witten\/Herdecke, Datteln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"bibr1-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003884"},{"key":"bibr2-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519829698"},{"key":"bibr3-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518775303"},{"key":"bibr4-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy154"},{"key":"bibr5-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000749"},{"key":"bibr6-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007032"},{"key":"bibr7-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520912379"},{"key":"bibr8-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517715132"},{"key":"bibr9-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008057"},{"key":"bibr10-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004312"},{"key":"bibr11-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-184"},{"key":"bibr12-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-320287"},{"key":"bibr13-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102833"},{"key":"bibr14-13524585221081090","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.647618"},{"key":"bibr15-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000708"},{"key":"bibr16-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02138-7"},{"key":"bibr17-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308346"},{"key":"bibr18-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316880"},{"key":"bibr19-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000926"},{"key":"bibr20-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119455"},{"key":"bibr21-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.779"},{"key":"bibr22-13524585221081090","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24364"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585221081090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585221081090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585221081090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:09:07Z","timestamp":1777694947000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585221081090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,14]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1177\/13524585221081090"],"URL":"https:\/\/doi.org\/10.1177\/13524585221081090","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,14]]}}}