{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:32:21Z","timestamp":1777937541366,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with relapsing disease, but clinical progression independent of relapse activity is rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To report progressive disease in a patient with MOGAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A single retrospective case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At 4\u2009years of age, the patient had a single episode of acute disseminated encephalomyelitis. She remained well until age 17\u2009years but over the next 9\u2009years developed progressive spastic quadriparesis, cognitive and bulbar dysfunction. Brain imaging showed a leukodystrophy-like pattern of white matter abnormality with contrast enhancement at different time points. Myelin oligodendrocyte glycoprotein (MOG)-IgG was repeatedly positive by live cell-based assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Secondary progression may be a rare presentation of MOG-IgG-associated disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585221090737","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T05:17:51Z","timestamp":1655961471000},"page":"1481-1484","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Progressive myelin oligodendrocyte glycoprotein-associated demyelination mimicking leukodystrophy"],"prefix":"10.1177","volume":"28","author":[{"given":"Emily","family":"Gibbons","sequence":"first","affiliation":[{"name":"National Neuromyelitis Optica Spectrum Disorders Service, The Walton Centre NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Whittam","sequence":"additional","affiliation":[{"name":"Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3453-3510","authenticated-orcid":false,"given":"Kariem","family":"Elhadd","sequence":"additional","affiliation":[{"name":"National Neuromyelitis Optica Spectrum Disorders Service, The Walton Centre NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maneesh","family":"Bhojak","sequence":"additional","affiliation":[{"name":"National Neuromyelitis Optica Spectrum Disorders Service, The Walton Centre NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitika","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, The Walton Centre NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivaram","family":"Avula","sequence":"additional","affiliation":[{"name":"Department of Radiology, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Jacob","sequence":"additional","affiliation":[{"name":"National Neuromyelitis Optica Spectrum Disorders Service, The Walton Centre NHS Foundation Trust, Liverpool, UK\/Cleveland Clinic, Abu Dhabi, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK\/National Institute for Health Research, Health Protection Research Unit on Emerging and Zoonotic Infections, University of Liverpool, UK\/Department of Neurology, Alderhey Children\u2019s NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif","family":"Huda","sequence":"additional","affiliation":[{"name":"National Neuromyelitis Optica Spectrum Disorders Service, The Walton Centre NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"bibr1-13524585221090737","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00340"},{"key":"bibr2-13524585221090737","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.01.053"},{"key":"bibr3-13524585221090737","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102964"},{"key":"bibr4-13524585221090737","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx276"},{"key":"bibr5-13524585221090737","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25909"},{"key":"bibr6-13524585221090737","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2940"},{"key":"bibr7-13524585221090737","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02132-y"},{"key":"bibr8-13524585221090737","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-313300"},{"key":"bibr9-13524585221090737","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012869"},{"key":"bibr10-13524585221090737","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13649"},{"key":"bibr11-13524585221090737","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102251"}],"container-title":["Multiple 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