{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:34:22Z","timestamp":1777937662481,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>In recent years, several disease-modifying therapies have been developed for the treatment of multiple sclerosis (MS). Cladribine transiently depletes B and T lymphocytes, with subsequent gradual cell recovery. No cases are reported in literature describing Cladribine drug-induced liver injury (DILI). We describe the case of a 19-year-old woman who developed acute idiosyncratic liver injury 12\u2009days after treatment with Cladribine. Post-marketing adverse event reporting is of paramount importance to allow an early recognition and treatment. Moreover, evaluation of the physiopathological mechanism underlying drug-induced hepatic toxicity can provide clinicians with valuable instruments for prevention and treatment.<\/jats:p>","DOI":"10.1177\/13524585221125360","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T08:49:09Z","timestamp":1664354949000},"page":"2142-2145","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute idiosyncratic liver injury after Cladribine treatment for multiple sclerosis: first case report and review on associated hepatic disorders"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-8406","authenticated-orcid":false,"given":"Lorenzo","family":"Saraceno","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Multiple Sclerosis Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy\/Department of Neurosciences, Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiammetta","family":"Pirro","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Multiple Sclerosis Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy\/Department of Neurosciences, Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Stigliano","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hepatitis Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio Clemente","family":"Agostoni","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Protti","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Multiple Sclerosis Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy\/Department of Neurosciences, Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"bibr1-13524585221125360","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01422-9"},{"key":"bibr2-13524585221125360","unstructured":"MAVENCLAD\u00ae European summary of product characteristics, https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/mavenclad-epar-product-information_en.pdf (2021, accessed 17 February 2021)."},{"key":"bibr3-13524585221125360","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-021-00842-9"},{"key":"bibr4-13524585221125360","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.12.032"},{"key":"bibr5-13524585221125360","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1064"},{"key":"bibr6-13524585221125360","unstructured":"National Institutes of Health. LiverTox: Cladribine, https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548555\/ (2017, accessed 16 February 2021)."},{"key":"bibr7-13524585221125360","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102572"},{"key":"bibr8-13524585221125360","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510391344"},{"key":"bibr9-13524585221125360","unstructured":"Clinical review(s), https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2019\/022561Orig1s000MedR.pdf (2019, accessed 17 February 2021)."},{"key":"bibr10-13524585221125360","unstructured":"US Department of Health and Human Services. Common Terminology Criteria for Adverse Events (CTCAE) version 50, https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/ctcae_v5_quick_reference_5x7.pdf (2017, accessed 17 February 2021)."},{"key":"bibr11-13524585221125360","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040803"},{"key":"bibr12-13524585221125360","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00196-9"},{"key":"bibr13-13524585221125360","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00121.2020"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585221125360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585221125360","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585221125360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:10:32Z","timestamp":1777695032000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585221125360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":13,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1177\/13524585221125360"],"URL":"https:\/\/doi.org\/10.1177\/13524585221125360","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]}}}