{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:33:25Z","timestamp":1777937605225,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2023,1]]},"abstract":"\n Background:<\/jats:title>\n \n Recently, satralizumab (interleukin-6 receptor blocker) was approved for seropositive neuromyelitis optica spectrum disorder (NMOSD) patients. In SAkuraSky trial, mild neutropenia was reported in 15% of patients under satralizumab. Most neutropenias were transient; grade 3\u20134 was not related to serious infections. So far, no severe neutropenia (<100 cell\/mm\n 3<\/jats:sup>\n ) has been reported worldwide.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We present an aquaporin-4-antibody-positive NMOSD patient who developed severe febrile neutropenia 2\u2009weeks after adding satralizumab to her azathioprine treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Analytic control for satralizumab is recommended at 4\u2009weeks. However, we recommend this control at week 2, in order to closely monitor neutrophil count and prevent further complications.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13524585221137231","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T01:23:47Z","timestamp":1669598627000},"page":"150-153","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Severe febrile neutropenia associated with satralizumab in an Argentinian neuromyelitis optica spectrum disorder patient"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-0215","authenticated-orcid":false,"given":"Claudia","family":"Pestchanker","sequence":"first","affiliation":[{"name":"Neurology Department, Hospital Central Dr. Ramon Carrillo, San Luis, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina","family":"Diaconchuk","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Central Dr. Ramon Carrillo, San Luis, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Lopez","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Central Dr. Ramon Carrillo, San Luis, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Rosa","family":"Monta\u00f1o","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Central Dr. Ramon Carrillo, San Luis, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Romero","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Central Dr. Ramon Carrillo, San Luis, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Zalazar","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Central Dr. Ramon Carrillo, San Luis, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-5726","authenticated-orcid":false,"given":"Edgar","family":"Carnero Contentti","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Neuroscience, Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"bibr1-13524585221137231","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02249-1"},{"key":"bibr2-13524585221137231","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901747"},{"key":"bibr3-13524585221137231","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30078-8"},{"key":"bibr4-13524585221137231","volume-title":"Presented at the Joint ACTRIMS-ECTRIMS, Virtual Meeting","author":"Greenberg B"},{"key":"bibr5-13524585221137231","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu035"},{"issue":"4","key":"bibr6-13524585221137231","first-page":"541","volume":"56","author":"Moots RJ","year":"2017","journal-title":"Rheumatology"},{"key":"bibr7-13524585221137231","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104025"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585221137231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585221137231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585221137231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:10:58Z","timestamp":1777695058000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585221137231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,27]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1177\/13524585221137231"],"URL":"https:\/\/doi.org\/10.1177\/13524585221137231","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,27]]}}}