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Many MS patients with TN have magnetic resonance imaging (MRI) evidence of a symptomatic demyelinating lesion. Although infratentorial presentations are included in the diagnostic criteria for MS, there remains confusion in clinical practice as to whether TN should be considered a clinically isolated syndrome for the application of McDonald criteria. In this case series, we discuss this diagnostic quandary in patients presenting with TN and additional MRI findings suggestive of MS and highlight the unmet need for data in such patients to optimally guide their care.<\/jats:p>","DOI":"10.1177\/13524585221149886","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:17:36Z","timestamp":1674778656000},"page":"637-641","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Should trigeminal neuralgia be considered a clinically isolated syndrome?"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-3190","authenticated-orcid":false,"given":"Sarasa","family":"Tohyama","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA\/Division of Brain, Imaging and Behaviour\u2014Systems 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