{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T10:39:03Z","timestamp":1793788743814,"version":"4.6.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"4-5","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Ministry of Health, Labour and Welfare of Japan","award":["20FC1030"],"award-info":[{"award-number":["20FC1030"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To our knowledge, no nationwide epidemiological study of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has been conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We examined the epidemiology and clinical features of MOGAD in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We distributed questionnaires on the clinical characteristics of patients with MOGAD to neurology, pediatric-neurology, and neuro-ophthalmology facilities throughout Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 887 patients were identified. The estimated number of total and newly diagnosed MOGAD patients was 1,695 [95% confidence interval (CI): 1483\u20131907] and 487 (95% CI: 414\u2013560), respectively. The estimated prevalence and incidence were 1.34\/100,000 (95% CI: 1.18\u20131.51) and 0.39\/100,000 (95% CI: 0.32\u20130.44), respectively. The median age at onset was 28\u2009years (range: 0\u201384\u2009years). At onset, optic neuritis was present in approximately 40% of patients, irrespective of the onset age. Acute disseminated encephalomyelitis was more frequent in younger patients, whereas brainstem encephalitis, encephalitis, and myelitis were more frequent in elderly patients. Immunotherapy was highly effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The prevalence and incidence rates of MOGAD in Japan are similar to those in other countries. Notable characteristics such as the preferential occurrence of acute disseminated encephalomyelitis in children exist; however, general characteristics including symptoms and treatment response are common irrespective of the onset age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585231156736","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T01:48:10Z","timestamp":1678499290000},"page":"530-539","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Epidemiological and clinical characteristics of myelin oligodendrocyte glycoprotein antibody-associated disease in a nationwide survey"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5248-5896","authenticated-orcid":false,"given":"Masashi","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juichi","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyuki","family":"Uzawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-9045","authenticated-orcid":false,"given":"Kengo","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagato","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Department of Social Health Medicine, Shizuoka Graduate University of Public Health, Shizuoka, Japan\/Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-8948","authenticated-orcid":false,"given":"Ichiro","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0112-x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1488"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000101"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005560"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000322"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa102"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.164"},{"key":"e_1_3_3_9_2","volume-title":"Nationwide epidemiologic survey manual for investigating the number of patients and clinico-epidemiological features of intractable disease","author":"Nakamura Y","year":"2017","unstructured":"Nakamura Y, Kawamura T, Fukushima W, et al. Nationwide epidemiologic survey manual for investigating the number of patients and clinico-epidemiological features of intractable disease. 3rd ed. Saitama, Japan: Japanese Ministry of Health and Welfare, 2017 (in Japanese).","edition":"3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008062"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1026-3"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25909"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2021.01.008"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012175"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007096"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517735191"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519845112"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103258"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513484547"},{"key":"e_1_3_3_22_2","first-page":"160","article-title":"The epidemiology of myelin oligodendrocyte glycoprotein antibody associated disorders","volume":"25","author":"Flanagan E","year":"2019","unstructured":"Flanagan E, Cabre P, St Sauver J, et al. The epidemiology of myelin oligodendrocyte glycoprotein antibody associated disorders. Mult Scler 2019; 25(Suppl. 2): 160.","journal-title":"Mult Scler"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-323158"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103884"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/ncn3.12479"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004312"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx276"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0718-0"},{"issue":"2","key":"e_1_3_3_29_2","first-page":"1022767","article-title":"Frequency of myelin oligodendrocyte glycoprotein antibodies in a large cohort of neurological patients","volume":"7","author":"Held F","year":"2021","unstructured":"Held F, Kalluri SR, Berthele A, et al. Frequency of myelin oligodendrocyte glycoprotein antibodies in a large cohort of neurological patients. Mult Scler J Exp Transl Clin 2021; 7(2): 1022767.","journal-title":"Mult Scler J Exp Transl Clin"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24117"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231156736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585231156736","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231156736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:11:33Z","timestamp":1777695093000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585231156736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,10]]},"references-count":29,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1177\/13524585231156736"],"URL":"https:\/\/doi.org\/10.1177\/13524585231156736","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,10]]}}}