{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:20:44Z","timestamp":1793186444930,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Paramagnetic rim lesions (PRLs) and slowly expanding lesions (SELs) have been posited as markers of chronic active lesions (CALs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the lesion-level concordance of PRLs and SELs in MS and to characterize changes in brain tissue integrity in CALs over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>MRIs were analyzed from a substudy of AFFINITY [NCT03222973], a phase 2 trial of opicinumab in relapsing MS. Assessments included (1) identification of SELs based on longitudinal MRIs over 72\u2009weeks, and identification of PRLs on susceptibility-weighted imaging (SWI) filtered phase images at week 72; (2) evaluation of subject-level correlation of SEL and PRL counts, volumes, and degree of lesion-level overlap between SELs and PRLs; and (3) characterization of tissue integrity over time in overlapping and non-overlapping SELs and PRLs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In 41 subjects, 119 chronic PRLs and 267 SELs were detected. Of 119 (39.5%) chronic PRLs, 47 co-localized with a SEL; 46\/267 (17.2%) SELs co-localized with a PRL. PRLs co-localized with SELs showed expansion and worsening microstructural damage over time. SELs with and without co-localization with PRLs showed ongoing tissue damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Chronic MS lesions identified as both PRL and SEL were associated with the most severe accumulation of tissue damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>AFFINITY [NCT03222973].<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585231162262","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T08:21:50Z","timestamp":1681114910000},"page":"680-690","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":71,"title":["Lesion-level correspondence and longitudinal properties of paramagnetic rim and slowly expanding lesions in multiple sclerosis"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3004-523X","authenticated-orcid":false,"given":"Colm","family":"Elliott","sequence":"first","affiliation":[{"name":"NeuroRx Research, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Rudko","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada\/McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, QC, Canada\/Department of Biomedical Engineering, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-0106","authenticated-orcid":false,"given":"Douglas L","family":"Arnold","sequence":"additional","affiliation":[{"name":"NeuroRx Research, Montreal, QC, Canada\/Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dumitru","family":"Fetco","sequence":"additional","affiliation":[{"name":"NeuroRx Research, Montreal, QC, Canada\/Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M","family":"Elkady","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada\/McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, QC, Canada\/Department of Biomedical Engineering, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Araujo","sequence":"additional","affiliation":[{"name":"NeuroRx Research, Montreal, QC, Canada\/Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3975-4366","authenticated-orcid":false,"given":"Bing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Gafson","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibeshih","family":"Belachew","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P","family":"Bradley","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Fisher","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"bibr1-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24497"},{"key":"bibr2-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1653-y"},{"key":"bibr3-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa117"},{"key":"bibr4-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy151"},{"key":"bibr5-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-093019-124155"},{"key":"bibr6-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1818-y"},{"key":"bibr7-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0240-y"},{"key":"bibr8-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr278"},{"key":"bibr9-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2399"},{"key":"bibr10-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86198"},{"key":"bibr11-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1636-z"},{"key":"bibr12-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy296"},{"key":"bibr13-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51338"},{"key":"bibr14-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518814117"},{"key":"bibr15-13524585231162262","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5660"},{"key":"bibr16-13524585231162262","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.21.26777"},{"key":"bibr17-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221102921"},{"key":"bibr18-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221114750"},{"issue":"9","key":"bibr19-13524585231162262","first-page":"1584","volume":"41","author":"Elliott C","year":"2020","journal-title":"Am J Neuroradiol"},{"key":"bibr20-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103048"},{"key":"bibr21-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz212"},{"key":"bibr22-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200144"},{"key":"bibr23-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001139"},{"key":"bibr24-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1364\/OL.28.001194"},{"key":"bibr25-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24897"},{"key":"bibr26-13524585231162262","volume-title":"Automatic lesion identification in MRI of multiple sclerosis patients","author":"Francis SJ","year":"2004"},{"key":"bibr27-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.10.015"},{"key":"bibr28-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab029"},{"key":"bibr29-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa436"},{"key":"bibr30-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103340"},{"key":"bibr31-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11082-2"},{"key":"bibr32-13524585231162262","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1212\/WNL.96.15_supplement.4106","volume":"96","author":"Elliott C","year":"2021","journal-title":"Neurology"},{"key":"bibr33-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516655403"},{"key":"bibr34-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1696-8"},{"key":"bibr35-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab448"},{"key":"bibr36-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30137-1"},{"key":"bibr37-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08477-6"},{"key":"bibr38-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12987"},{"key":"bibr39-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001138"},{"key":"bibr40-13524585231162262","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221141964"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231162262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585231162262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231162262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:11:42Z","timestamp":1777695102000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585231162262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1177\/13524585231162262"],"URL":"https:\/\/doi.org\/10.1177\/13524585231162262","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,10]]}}}