{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:34:25Z","timestamp":1777937665737,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>Cerebellar dysfunction is likely to cause severe and treatment-resistant disability in multiple sclerosis (MS). Certain spinocerebellar ataxia (SCA)-related alleles can increase MS susceptibility, and channel polymorphisms can impact disability measures. Following an index patient with the coexistence of MS and SCA Type-8 (SCA8) in the MS clinic, an institutional engine search for MS and hereditary ataxia coexistence was conducted but did not reveal any other cases. This extremely rare coexistence of MS and SCA8 in our index patient may be incidental; however, a yet-to-be-identified contribution of coexistent hereditary ataxia(s) to the susceptibility of a prominent progressive ataxia MS phenotype cannot be ruled out.<\/jats:p>","DOI":"10.1177\/13524585231180549","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T01:22:50Z","timestamp":1688433770000},"page":"1195-1198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Coexistence of multiple sclerosis and spinocerebellar ataxia type-8"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-4271","authenticated-orcid":false,"given":"Nur","family":"Neyal","sequence":"first","affiliation":[{"name":"Nur Neyal Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-935X","authenticated-orcid":false,"given":"B Mark","family":"Keegan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orhun H","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Department of Medical Genetics, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2270-9868","authenticated-orcid":false,"given":"Burcu","family":"Zeydan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Women\u2019s Health Research Center, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"bibr1-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002338"},{"key":"bibr2-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002326"},{"key":"bibr3-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1007\/s100480050058"},{"key":"bibr4-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-012-0403-5"},{"key":"bibr5-13524585231180549","unstructured":"Cleary JD, Subramony SH, Ranum LPW. Spinocerebellar ataxia type 8. In: Adam MP, Everman DB, Mirzaa GM, et al. (eds) GeneReviews((R)) [Internet]. Seattle, WA, 1993\u2013 2023. Available at: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1268\/ (accessed 20 December 2022)."},{"key":"bibr6-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.08.014"},{"key":"bibr7-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-005-0447-0"},{"key":"bibr8-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d7d8a0"},{"key":"bibr9-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.2.217"},{"key":"bibr10-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512469696"},{"key":"bibr11-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003798117"},{"key":"bibr12-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.06.001"},{"key":"bibr13-13524585231180549","doi-asserted-by":"publisher","DOI":"10.1038\/srep29489"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231180549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585231180549","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231180549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:12:09Z","timestamp":1777695129000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585231180549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,3]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1177\/13524585231180549"],"URL":"https:\/\/doi.org\/10.1177\/13524585231180549","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,3]]}}}