{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:01:31Z","timestamp":1793073691762,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Roche Argentina","award":["STUDIO SL43969"],"award-info":[{"award-number":["STUDIO SL43969"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We aimed to assess the frequency of new asymptomatic lesions on brain and spinal imaging (magnetic resonance imaging (MRI)) and their association with subsequent relapses in a large cohort of neuromyelitis optica spectrum disorder (NMOSD) patients in Argentina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively reviewed 675 MRI (225 performed during an attack and 450 during the relapse-free period (performed at least 3 months from the last attack)) of NMOSD patients who had at least 2 years of clinical and MRI follow-up since disease onset. Kaplan\u2013Meier (KM) curves were used for depicting time from remission MRI to subsequent relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We included 135 NMOSD patients (64.4% were aquaporin-4-immunoglobulin G (AQP4-IgG)-positive). We found that 26 (19.26%) and 66 (48.88%) of patients experienced at least one new asymptomatic MRI lesion during both the relapse-free period and attacks, respectively. The most frequent asymptomatic MRI lesions were optic nerves followed by short-segment myelitis during the relapse-free period and attacks. KM curves did not show differences in the time taken to develop a new relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings showed that new asymptomatic lesions are relatively frequent. However, the presence of new asymptomatic MRI lesions during the relapse-free period and at relapses was not associated with a shorter time to developing subsequent relapses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585231187120","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T02:11:41Z","timestamp":1690337501000},"page":"1240-1249","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Frequency of new asymptomatic MRI lesions during attacks and follow-up of patients with NMOSD in a real-world setting"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-5726","authenticated-orcid":false,"given":"Edgar","family":"Carnero Contentti","sequence":"first","affiliation":[{"name":"Neuroimmunology Unit, Department of Neurosciences, Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo A","family":"Lopez","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Neurosciences, Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Tkachuk","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Enfermedades Desmielinizantes, Servicio de Neurolog\u00eda, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Vrech","sequence":"additional","affiliation":[{"name":"Departamento de Enfermedades Desmielinizantes, Sanatorio Allende, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A","family":"Zarate","sequence":"additional","affiliation":[{"name":"Departamento de Enfermedades Desmielinizantes, Sanatorio Allende, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Correale","sequence":"additional","affiliation":[{"name":"Departamento de Neurolog\u00eda, Fleni, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Deri","sequence":"additional","affiliation":[{"name":"Centro de Especialidades Neurol\u00f3gicas y Rehabilitaci\u00f3n, CENyR, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5716-6082","authenticated-orcid":false,"given":"Geraldine","family":"Luetic","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-8375","authenticated-orcid":false,"given":"Mariano","family":"Marrodan","sequence":"additional","affiliation":[{"name":"Departamento de Neurolog\u00eda, Fleni, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Pagani Cassara","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Fundaci\u00f3n Favaloro\/INECO\/Buenos Aires, Argentina Servicio de Neurolog\u00eda, Hospital Universitario Austral, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar\u00edo","family":"Tavolini","sequence":"additional","affiliation":[{"name":"INECO Neurociencias Oro\u00f1o, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda C\u00e9lica","family":"Ysrraelit","sequence":"additional","affiliation":[{"name":"Departamento de Neurolog\u00eda, Fleni, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda E","family":"Balbuena","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Enfermedades Desmielinizantes, Servicio de Neurolog\u00eda, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Hryb","sequence":"additional","affiliation":[{"name":"Consultorio de Neuroinmunolog\u00eda, Hospital Carlos G. Durand, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Chiganer","sequence":"additional","affiliation":[{"name":"Consultorio de Neuroinmunolog\u00eda, Hospital Carlos G. Durand, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felisa","family":"Leguizamon","sequence":"additional","affiliation":[{"name":"Hospital de Agudos, Dr. Teodoro \u00c1lvarez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Knorre","sequence":"additional","affiliation":[{"name":"Hospital de Agudos, Dr. Teodoro \u00c1lvarez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Zanga","sequence":"additional","affiliation":[{"name":"Departamento de Neurolog\u00eda, Hospital Cesar Milstein, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-0215","authenticated-orcid":false,"given":"Claudia","family":"Pestchanker","sequence":"additional","affiliation":[{"name":"Hospital Central Dr. Ram\u00f3n Carrillo, San Luis, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Barboza","sequence":"additional","affiliation":[{"name":"Hospital Central de Mendoza, Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Nadur","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Enfermedades Desmielinizantes, Servicio de Neurolog\u00eda, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Cristiano","sequence":"additional","affiliation":[{"name":"Centro de Esclerosis M\u00faltiple de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Patrucco","sequence":"additional","affiliation":[{"name":"Centro de Esclerosis M\u00faltiple de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-8343","authenticated-orcid":false,"given":"Ricardo","family":"Alonso","sequence":"additional","affiliation":[{"name":"Centro Universitario de Esclerosis M\u00faltiple, Hospital Ramos Mej\u00eda, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Alonso Serena","sequence":"additional","affiliation":[{"name":"Servicio de Cl\u00ednica M\u00e9dica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Center, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Freie Universit\u00e4t Berlin, Berlin, Germany"},{"name":"Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Berlin Institute of Health, Berlin, Germany"},{"name":"Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ignacio","family":"Rojas","sequence":"additional","affiliation":[{"name":"Centro de Esclerosis M\u00faltiple de Buenos Aires, Buenos Aires, Argentina Servicio de Neurolog\u00eda, Unidad de EM y Enfermedades Desmielinizantes, Hospital Universitario de CEMIC, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"bibr1-13524585231187120","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"bibr2-13524585231187120","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02249-1"},{"key":"bibr3-13524585231187120","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001367"},{"key":"bibr4-13524585231187120","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13836"},{"key":"bibr5-13524585231187120","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24554"},{"key":"bibr6-13524585231187120","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010847"},{"key":"bibr7-13524585231187120","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167783"},{"key":"bibr8-13524585231187120","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.37833"},{"key":"bibr9-13524585231187120","first-page":"118","volume":"26","author":"Paul 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