{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:40:00Z","timestamp":1785807600598,"version":"3.56.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"11-12","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Radiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine functional connectivity differences between RIS and healthy controls using resting-state functional magnetic resonance imaging (fMRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Resting-state fMRI data in 25 RIS patients and 28 healthy controls were analyzed using an independent component analysis; in addition, seed-based correlation analysis was used to obtain more information about specific differences in the functional connectivity of resting-state networks. Participants also underwent neuropsychological testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      RIS patients did not differ from the healthy controls regarding age, sex, and years of education. However, in memory (verbal and visuospatial) and executive functions, RIS patients\u2019 cognitive performance was significantly worse than the healthy controls. In addition, fluid intelligence was also affected. Twelve out of 25 (48%) RIS patients failed at least one cognitive test, and six (24.0%) had cognitive impairment. Compared to healthy controls, RIS patients showed higher functional connectivity between the default mode network and the right middle and superior frontal gyri and between the central executive network and the right thalamus ( p\n                      <jats:sub>FDR<\/jats:sub>\n                      &lt; 0.05; corrected). In addition, the seed-based correlation analysis revealed that RIS patients presented higher functional connectivity between the posterior cingulate cortex, an important hub in neural networks, and the right precuneus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>RIS patients had abnormal brain connectivity in major resting-state neural networks and worse performance in neurocognitive tests. This entity should be considered not an \u201cincidental finding\u201d but an exclusively non-motor (neurocognitive) variant of multiple sclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585231195851","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:26:41Z","timestamp":1695968801000},"page":"1393-1405","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-4809","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Benito-Le\u00f3n","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital \u201c12 de Octubre,\u201d Madrid, Spain"},{"name":"Research Institute (i+12), University Hospital \u201c12 de Octubre\u201d, Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED) Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Bel\u00e9n","family":"del Pino","sequence":"additional","affiliation":[{"name":"Medical Image Analysis and Biometry Laboratory (LAIMBIO), Rey Juan Carlos University, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Aladro","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Getafe, Madrid, Spain"},{"name":"Faculty of Biomedical and Health Sciences, European University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Cuevas","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201c12 de Octubre,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-3034","authenticated-orcid":false,"given":"\u00c1ngela","family":"Domingo-Santos","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201c12 de Octubre,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Gal\u00e1n S\u00e1nchez-Seco","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201c12 de Octubre,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Labiano-Fontcuberta","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201c12 de Octubre,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5063-439X","authenticated-orcid":false,"given":"Ana","family":"G\u00f3mez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201c12 de Octubre,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Salgado-C\u00e1mara","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201c12 de Octubre,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucienne","family":"Costa-Frossard","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201cRam\u00f3n y Cajal,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Monreal","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201cRam\u00f3n y Cajal,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Sainz de la Maza","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201cRam\u00f3n y Cajal,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-2708","authenticated-orcid":false,"given":"Jordi A","family":"Mat\u00edas-Guiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Hospital Cl\u00ednico \u201cSan Carlos,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mat\u00edas-Guiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Hospital Cl\u00ednico \u201cSan Carlos,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1889-4503","authenticated-orcid":false,"given":"Alfonso","family":"Delgado-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Hospital Cl\u00ednico \u201cSan Carlos,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Montero-Escribano","sequence":"additional","affiliation":[{"name":"Department of Neurology, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Hospital Cl\u00ednico \u201cSan Carlos,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Mart\u00ednez-Gin\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201cGregorio Mara\u00f1\u00f3n,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Higueras","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201cGregorio Mara\u00f1\u00f3n,\u201d Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Ayuso-Peralta","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201cPr\u00edncipe de Asturias,\u201d Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto","family":"Malpica","sequence":"additional","affiliation":[{"name":"Medical Image Analysis and Biometry Laboratory (LAIMBIO), Rey Juan Carlos University, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5373-6711","authenticated-orcid":false,"given":"Helena","family":"Melero","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiolog\u00eda y Metodolog\u00eda en Ciencias del Comportamiento, Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"bibr1-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335764.14513.1a"},{"key":"bibr2-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004101"},{"key":"bibr3-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003208"},{"key":"bibr4-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13923"},{"key":"bibr5-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102749"},{"key":"bibr6-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516653666"},{"key":"bibr7-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25799"},{"key":"bibr8-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000102"},{"key":"bibr9-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6410(01)00010-6"},{"key":"bibr10-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.05.008"},{"key":"bibr11-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510375707"},{"key":"bibr12-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824528c9"},{"key":"bibr13-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515591072"},{"key":"bibr14-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001936"},{"key":"bibr15-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004310"},{"key":"bibr16-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24730"},{"key":"bibr17-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2557-14.2015"},{"issue":"1","key":"bibr18-13524585231195851","first-page":"1","volume":"418","author":"Soman SM","year":"2020","journal-title":"J Neurol Sci"},{"issue":"1","key":"bibr19-13524585231195851","first-page":"1","volume":"10","author":"Yu Y","year":"2020","journal-title":"Res Sq"},{"key":"bibr20-13524585231195851","volume-title":"Essentials of WAIS-III assessment","author":"Kaufman AS","year":"1999"},{"key":"bibr21-13524585231195851","volume-title":"A manual for the brief repeatable battery of neuropsychological tests in multiple sclerosis","author":"Rao SM","year":"1990"},{"key":"bibr22-13524585231195851","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00557"},{"key":"bibr23-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2021.1952590"},{"key":"bibr24-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"bibr25-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.05.042"},{"key":"bibr26-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0235-4"},{"key":"bibr27-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0327-3"},{"key":"bibr28-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042"},{"key":"bibr29-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.032"},{"key":"bibr30-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.10.012"},{"key":"bibr31-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-016-1654-5"},{"key":"bibr32-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.07.035"},{"key":"bibr33-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200033797"},{"key":"bibr34-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.018"},{"key":"bibr35-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"bibr36-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1634"},{"key":"bibr37-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/868976"},{"key":"bibr38-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"bibr39-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2250-06.2006"},{"key":"bibr40-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq058"},{"key":"bibr41-13524585231195851","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1358"},{"key":"bibr42-13524585231195851","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3608"},{"key":"bibr43-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab237"},{"key":"bibr44-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4490-4"},{"key":"bibr45-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.10.031"},{"key":"bibr46-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826d5f10"},{"key":"bibr47-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13112"},{"key":"bibr48-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/212693"},{"key":"bibr49-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231868"},{"key":"bibr50-13524585231195851","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-022-01198-4"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231195851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585231195851","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231195851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:12:42Z","timestamp":1777695162000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585231195851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":50,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/13524585231195851"],"URL":"https:\/\/doi.org\/10.1177\/13524585231195851","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,29]]}}}