{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:54:52Z","timestamp":1792076092948,"version":"4.4.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["390857198"],"award-info":[{"award-number":["390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","award":["RIA 733161"],"award-info":[{"award-number":["RIA 733161"]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Infections are discussed as risk factor for multiple sclerosis (MS) development and relapses. This may lead to decreased vaccination frequency in newly diagnosed patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the relation of MS diagnosis to subsequent vaccination frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Based on German ambulatory claims data from 2005 to 2019, regression models were used to assess the relation of MS diagnosis ( n = 12,270) to vaccination. A cohort of patients with MS was compared to control cohorts with Crohn\u2019s disease, psoriasis, and without these autoimmune diseases (total n = 198,126) in the 5 years after and before diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients with MS were less likely to be vaccinated compared to persons without the autoimmune diseases 5 years after diagnosis (odds ratio = 0.91, p &lt; 0.001). Exceptions were vaccinations against influenza (1.29, p &lt; 0.001) and pneumococci (1.41, p &lt; 0.001). Differences were strong but less pronounced after than before diagnosis ( p &lt; 0.001). The likelihood of vaccination was also lower compared to patients with Crohn\u2019s disease or psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with MS were not adequately vaccinated despite guideline recommendations. Increasing awareness about the importance of vaccination is warranted to reduce the risk of infection, in particular, in patients with MS receiving immunotherapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585231199084","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:19:25Z","timestamp":1697177965000},"page":"1831-1840","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Vaccination frequency in people newly diagnosed with multiple sclerosis"],"prefix":"10.1177","volume":"29","author":[{"given":"Sonia","family":"Darvishi","sequence":"first","affiliation":[{"name":"Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0668-0049","authenticated-orcid":false,"given":"Ewan","family":"Donnachie","sequence":"additional","affiliation":[{"name":"Bavarian Association of Statutory Health Insurance Physicians, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Gasperi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hapfelmeier","sequence":"additional","affiliation":[{"name":"Institute of General Practice and Health Services Research, Technical University of Munich, Munich, Germany"},{"name":"Institute of AI and Informatics in Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-6784","authenticated-orcid":false,"given":"Bernhard","family":"Hemmer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"bibr1-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520970841"},{"key":"bibr2-13524585231199084","unstructured":"(msif) Msif. Atlas of MS. https:\/\/www.atlasfms.org\/map\/germany\/epidemiology\/number-of-people-with-ms (2022, accessed 25 July 2022)."},{"key":"bibr3-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.187"},{"key":"bibr4-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30481-1"},{"key":"bibr5-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj8222"},{"key":"bibr6-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-020-00756-y"},{"key":"bibr7-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102420"},{"key":"bibr8-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.3365"},{"key":"bibr9-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.101982"},{"key":"bibr10-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103285"},{"key":"bibr11-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00595-2"},{"key":"bibr12-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000824"},{"key":"bibr13-13524585231199084","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01883"},{"key":"bibr14-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5377.630"},{"key":"bibr15-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102013440502"},{"key":"bibr16-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.2633"},{"key":"bibr17-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008012"},{"key":"bibr18-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.2.312"},{"key":"bibr19-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511417253"},{"key":"bibr20-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-5944-x"},{"key":"bibr21-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102013440501"},{"key":"bibr22-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327200"},{"key":"bibr23-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8263-4"},{"key":"bibr24-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008157"},{"key":"bibr25-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520952310"},{"key":"bibr26-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103236"},{"key":"bibr27-13524585231199084","doi-asserted-by":"publisher","DOI":"10.2307\/2531734"},{"key":"bibr28-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.200810425"},{"key":"bibr29-13524585231199084","unstructured":"Robert Koch Institute. Recommendations of the Standing Commission on Vaccination (STIKO) at the Robert Koch Institute. Epidemiologisches Bulletin 4\/2022, https:\/\/www.rki.de\/EN\/Content\/infections\/Vaccination\/recommandations\/04_22_englisch.pdf?__blob=publicationFile"},{"key":"bibr30-13524585231199084","unstructured":"Centers for Disease Control and Prevention. Recommended adult immunization schedule for ages 19 years or older, United States, 2020. 2022, https:\/\/www.cdc.gov\/vaccines\/schedules\/hcp\/imz\/adult.html"},{"key":"bibr31-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000001099"},{"key":"bibr32-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1177\/11795735211042188"},{"key":"bibr33-13524585231199084","first-page":"3","volume":"47","author":"Rieck T","year":"2020","journal-title":"Epid Bull"},{"key":"bibr34-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92801-6"},{"key":"bibr35-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7002.422a"},{"key":"bibr36-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.2.396"},{"key":"bibr37-13524585231199084","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050677"},{"key":"bibr38-13524585231199084","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102947"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231199084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585231199084","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231199084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:13:05Z","timestamp":1777695185000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585231199084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":38,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/13524585231199084"],"URL":"https:\/\/doi.org\/10.1177\/13524585231199084","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,13]]}}}