{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:16:13Z","timestamp":1779333373491,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01606"],"award-info":[{"award-number":["PI19\/01606"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008659","name":"European Committee for Treatment and Research in Multiple Sclerosis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Mumps-Measles-Rubella (MMR) and Varicella zoster vaccines (VAR) are live attenuated vaccines, usually administered in a two-dose scheme at least 4\u2009weeks apart. However, single-dose immunization schemes may also be effective and can reduce delays in immunosuppressive treatment initiation in patients with multiple sclerosis (pwMS) who need to be immunized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the immunogenicity of a single-dose attempt (SDA) versus the standard immunization scheme (SIS) with VAR and\/or MMR in pwMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective observational study in pwMS vaccinated against VAR and\/or MMR. We compared seroprotection rates and antibody geometric mean titers (GMTs) between the two strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Ninety-six patients were included. Thirty-one patients received VAR and 67 MMR. In the SDA group, the seroprotection rate was 66.7% (95% confidence interval (CI): 53.3\u201378.3) versus 97.2% (95% CI: 85.5\u201399.9) in the SIS ( p\u2009&lt;\u20090.001). For the seroprotected patients, GMTs were similar for both schemes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>An SDA of VAR and\/or MMR vaccines could be sufficient to protect almost two-thirds of patients. Testing immunogenicity after a single dose of VZ and\/or MMR could be included in routine clinical practice to achieve rapid immunization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585231200303","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T09:04:26Z","timestamp":1695200666000},"page":"1841-1848","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["A single-dose strategy for immunization with live attenuated vaccines is an effective option before treatment initiation in multiple sclerosis patients"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-8412","authenticated-orcid":false,"given":"Ren\u00e9","family":"Carvajal","sequence":"first","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Pg. Vall d\u2019Hebron, 119-129, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-3184","authenticated-orcid":false,"given":"Carmen","family":"Tur","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Mart\u00ednez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Epidemiology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bollo","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Esperalba","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain\/CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6364-9497","authenticated-orcid":false,"given":"Agust\u00edn","family":"Pappolla","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-0721","authenticated-orcid":false,"given":"Alvaro","family":"Cobo-Calvo","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Carbonell","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Borras-Bemejo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Epidemiology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4546-7627","authenticated-orcid":false,"given":"Jordi","family":"R\u00edo","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Castill\u00f3","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathane","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neus","family":"Mongay-Ochoa","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 \u00c1ngel","family":"Rodrigo-Pend\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Epidemiology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-5507","authenticated-orcid":false,"given":"\u00c1ngela","family":"Vidal-Jordana","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-5510","authenticated-orcid":false,"given":"Georgina","family":"Arrambide","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-753X","authenticated-orcid":false,"given":"Breog\u00e1n","family":"Rodr\u00edguez-Acevedo","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-5251","authenticated-orcid":false,"given":"Ana","family":"Zabalza","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Midaglia","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Gal\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Comabella","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1589-2254","authenticated-orcid":false,"given":"Jaume","family":"Sastre-Garriga","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Montalban","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain\/Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-5359","authenticated-orcid":false,"given":"Mar","family":"Tintor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain\/Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Otero-Romero","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain\/ Department of Preventive Medicine and Epidemiology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"bibr1-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2021.1886924"},{"key":"bibr2-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000929"},{"key":"bibr3-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231168043"},{"key":"bibr4-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15809"},{"key":"bibr5-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3741"},{"key":"bibr6-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv105"},{"key":"bibr7-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20740"},{"key":"bibr8-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.4655"},{"key":"bibr9-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317509"},{"key":"bibr10-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00131-10"},{"key":"bibr11-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.02.074"},{"key":"bibr12-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200204000-00014"},{"key":"bibr13-13524585231200303","first-page":"87","volume":"69","author":"World Health Assembly (27th: 1974)","year":"1985","journal-title":"Assignment Child"},{"key":"bibr14-13524585231200303","unstructured":"WHO. Provisional data based on monthly data reported to WHO, https:\/\/www.who.int\/news\/item\/27-04-2022-unicef-and-who-warn-of\u2013perfect-storm\u2013of-conditions-for-measles-outbreaks\u2013affecting-children"},{"key":"bibr15-13524585231200303","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10111859"},{"key":"bibr16-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211069068"},{"key":"bibr17-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac299"},{"issue":"11","key":"bibr18-13524585231200303","volume":"11","author":"Di Pietrantonj C","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr19-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00479-7"},{"key":"bibr20-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1871296"},{"key":"bibr21-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1157\/13100461"},{"key":"bibr22-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1016\/j.semerg.2019.12.012"},{"key":"bibr23-13524585231200303","doi-asserted-by":"publisher","DOI":"10.1086\/522130"},{"key":"bibr24-13524585231200303","unstructured":"Calendarios de inmunizaci\u00f3n en Espa\u00f1a, https:\/\/vacunasaep.org\/documentos\/manual\/cap-7#f7.10"},{"key":"bibr25-13524585231200303","unstructured":"CDC, https:\/\/www.cdc.gov\/vaccines\/pubs\/pinkbook\/varicella.html"},{"key":"bibr26-13524585231200303","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v36i00a10"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231200303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585231200303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231200303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:13:10Z","timestamp":1777695190000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585231200303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":26,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/13524585231200303"],"URL":"https:\/\/doi.org\/10.1177\/13524585231200303","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]}}}