{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:37:49Z","timestamp":1777937869645,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Late-onset neutropenia (LON), defined as an absolute neutrophil count (ANC) &lt; 1500\/mm\n                      <jats:sup>3<\/jats:sup>\n                      that develops between 4 weeks and 6 months after the last drug administration, is a rare side effect of anti-CD20 drugs including ocrelizumab. Although continuation of ocrelizumab after LON is not contraindicated, the risk of LON recurrence is not well known.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Cases:<\/jats:title>\n                    <jats:p>\n                      We report three cases of recurrent symptomatic agranulocytosis (ANC &lt; 500\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ) occurring under ocrelizumab.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Given the risk of recurrence of symptomatic agranulocytosis and the availability of other treatments, a therapeutic switch may be discussed after the first episode of LON.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585231206218","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T07:21:56Z","timestamp":1698391316000},"page":"131-133","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Recurrence of severe symptomatic late-onset neutropenia on ocrelizumab"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-1865","authenticated-orcid":false,"given":"Ysoline","family":"Beigneux","sequence":"first","affiliation":[{"name":"Sorbonne University, Paris Brain Institute \u2013 ICM, Assistance Publique H\u00f4pitaux de Paris, Department of Neurology, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"Louapre","sequence":"additional","affiliation":[{"name":"Sorbonne University, Paris Brain Institute \u2013 ICM, Assistance Publique H\u00f4pitaux de Paris, Department of Neurology, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Bihan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Regional Pharmacovigilance Center, Sorbonne Universit\u00e9, AP-HP. Sorbonne Universit\u00e9, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, INSERM, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-9943","authenticated-orcid":false,"given":"Thomas","family":"Roux","sequence":"additional","affiliation":[{"name":"Sorbonne University, Paris Brain Institute \u2013 ICM, Assistance Publique H\u00f4pitaux de Paris, Department of Neurology, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"de Paz","sequence":"additional","affiliation":[{"name":"Sorbonne University, Paris Brain Institute \u2013 ICM, Assistance Publique H\u00f4pitaux de Paris, Department of Neurology, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Lubetzki","sequence":"additional","affiliation":[{"name":"Sorbonne University, Paris Brain Institute \u2013 ICM, Assistance Publique H\u00f4pitaux de Paris, Department of Neurology, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-0328","authenticated-orcid":false,"given":"Elisabeth","family":"Maillart","sequence":"additional","affiliation":[{"name":"Sorbonne University, Paris Brain Institute \u2013 ICM, Assistance Publique H\u00f4pitaux de Paris, Department of Neurology, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"bibr1-13524585231206218","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2021.06.007"},{"key":"bibr2-13524585231206218","doi-asserted-by":"publisher","DOI":"10.1002\/art.41501"},{"key":"bibr3-13524585231206218","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-021-01516-8"},{"key":"bibr4-13524585231206218","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.0274"},{"key":"bibr5-13524585231206218","doi-asserted-by":"publisher","DOI":"10.1016\/j.nerep.2022.100136"},{"key":"bibr6-13524585231206218","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116603"},{"key":"bibr7-13524585231206218","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104090"},{"key":"bibr8-13524585231206218","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006924"},{"key":"bibr9-13524585231206218","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012700"},{"key":"bibr10-13524585231206218","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05379-9"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231206218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585231206218","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231206218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:13:30Z","timestamp":1777695210000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585231206218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/13524585231206218"],"URL":"https:\/\/doi.org\/10.1177\/13524585231206218","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,27]]}}}