{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:23:36Z","timestamp":1790792616163,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dimethyl fumarate (DMF) has a favorable benefit\u2013risk profile treating people with multiple sclerosis and should be used in pregnant women only if the potential benefits outweigh potential risks to the fetus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Assess pregnancy outcomes in a completed international registry (TecGistry) of women with MS exposed to DMF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>TecGistry included pregnant women with MS exposed to DMF, with data collected at enrollment, 6\u20137 months gestation, 4 weeks after estimated due date, and at postpartum weeks 4, 12, and 52. Outcomes included live births, gestational size, pregnancy loss, ectopic\/molar pregnancies, birth defects, and infant\/maternal death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 397 enrolled, median (range) age was 32 years (19\u201343). Median (range) gestational week at enrollment was 10 (0\u201339) and at first DMF exposure was 1 (0\u201313). Median (range) duration of gestational DMF exposure was 5 weeks (0\u201340). Fifteen (3.8%) spontaneous abortions occurred. Of 360 (89.1%) live births, 323 were full term and 37 were premature. One neonatal death and no maternal deaths occurred. Adjudicator-confirmed EUROCAT birth defects were found in 2.2%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>DMF exposure during pregnancy did not adversely affect pregnancy outcomes; birth defects, preterm birth, and spontaneous abortion were in line with rates from the general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585231220232","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T02:10:41Z","timestamp":1704247841000},"page":"209-215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Final analysis of 379 pregnancy outcomes after exposure to dimethyl fumarate in a prospective international registry"],"prefix":"10.1177","volume":"30","author":[{"given":"Kerstin","family":"Hellwig","sequence":"first","affiliation":[{"name":"Neurological Clinic, University of Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rog","sequence":"additional","affiliation":[{"name":"Manchester Centre for Clinical Neurosciences, Salford Care Organisation, Northern Care Alliance NHS Foundation Trust, Salford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"McGuigan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University College Dublin and St. Vincent\u2019s University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6077-0654","authenticated-orcid":false,"given":"Maria K","family":"Houtchens","sequence":"additional","affiliation":[{"name":"The Partners MS Center, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise R","family":"Bruen","sequence":"additional","affiliation":[{"name":"Adult Neurology Clinic, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Mokliatchouk","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"Branco","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Levin","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7216-7836","authenticated-orcid":false,"given":"Nicholas","family":"Everage","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Lin","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"bibr1-13524585231220232","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520970841"},{"key":"bibr2-13524585231220232","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-015-0238-y"},{"key":"bibr3-13524585231220232","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114287"},{"key":"bibr4-13524585231220232","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206328"},{"key":"bibr5-13524585231220232","unstructured":"Biogen. 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