{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:35:58Z","timestamp":1777937758808,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"EDMUS Foundation"},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ARSEP Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Counseling on pregnancy is still challenging, particularly regarding the use of disease-modifying treatments (DMTs). We are lacking long-term outcomes in children exposed to DMTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to set up a French pregnancy registry for women with multiple sclerosis (MS) and related disorders nested within the Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques (OFSEP) cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective, observational, multicentric, epidemiological study in France. Neurological visits are organized according to routine practice. Data are collected on the OFSEP minimal datasheet. Auto-questionnaires on pregnancy are completed by patients at Months 5\u20136 and 8 during pregnancy, and Months 3, 6, and 12 postpartum. A specific survey on analgesia is completed by anesthesiologists. Pediatric data are collected from the child\u2019s health book, where visits on Day 8, Month 9, and 24 are mandatory. Parents complete neurodevelopmental questionnaires at Year 1, Years 2 and 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The RESPONSE study started in August 2019. On 7 April 2023, 515 women were included. Baseline demographics are presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>RESPONSE will provide rich information on the global management of pregnancy in France and prospective data on children until the age of 6 years, exposed or not to a DMT, including data on neurodevelopment that can be compared to the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study funding:<\/jats:title>\n                    <jats:p>EDMUS and ARSEP Foundation, Biogen, Roche.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585231223390","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T07:35:41Z","timestamp":1704958541000},"page":"216-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Response Study: A French registry on pregnancy in women with MS and related disorders and their children up to 6 years\u2014Protocol, recruitment status, and baseline characteristics"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7337-7122","authenticated-orcid":false,"given":"Sandra","family":"Vukusic","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon, Service de Neurologie, Scl\u00e9rose en Plaques, Pathologies de la My\u00e9line et Neuro-Inflammation\u2014H\u00f4pital Neurologique Pierre Wertheimer, Bron Cedex, France"},{"name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, Centre de Recherche 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INSERM 1028 et CNRS UMR 5292, Lyon, France"},{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"Eug\u00e8ne Devic EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation, Bron Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumaran","family":"Deiva","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2014H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux Universitaires Paris Saclay, Site Bic\u00eatre, Service de Neurologie P\u00e9diatrique, CRMR Maladies Inflammatoires Rares du Cerveau et de la Moelle (MIRCEM), UMR 1184, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Guennoc","sequence":"additional","affiliation":[{"name":"CRC SEP, Department of neurology, CHU de Tours, Tours, 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Wertheimer, Bron Cedex, France"},{"name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, Lyon, France"},{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"Eug\u00e8ne Devic EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation, Bron Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakhdar","family":"Benyahya","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Service de Neurologie, Scl\u00e9rose en Plaques, Pathologies de la My\u00e9line et Neuro-Inflammation\u2014H\u00f4pital Neurologique Pierre Wertheimer, Bron Cedex, France"},{"name":"Hospices Civils de Lyon, H\u00f4pital Neurologique Pierre Wertheimer, Centre de R\u00e9f\u00e9rence des Maladies Inflammatoires Rares du Cerveau et de la Moelle (MIRCEM), Bron Cedex, 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