{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T18:04:25Z","timestamp":1793988265489,"version":"4.8.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) frequently affects women of childbearing age and pregnant women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the use of MS disease-modifying therapies (DMTs) during pregnancy in France over the last decade, marked by an increasing DMTs availability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All pregnancies ended from April 2010 to December 2021 in women with MS were identified based on the nationwide Mother\u2013Child Register EPI-MERES, built from the French National Health Data System ( Syst\u00e8me National des Donn\u00e9es de Sant\u00e9 (SNDS)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of a total of 20,567 pregnancies in women with MS, 7587 were exposed to DMT. The number of DMT-exposed pregnancies markedly increased from 1079 in 2010\u20132012 to 2413 in 2019\u20132021 (+124%), especially those exposed to glatiramer acetate, natalizumab, dimethyl fumarate, and anti-CD20. Among pregnancies of women on DMT 6 months before pregnancy, 78.0% underwent DMT discontinuation and 7.6% switched DMT, generally before (33.0% and 77.0%, respectively) or during the first trimester of pregnancy (58.3% and 17.8%, respectively). DMT discontinuation decreased from 84.0% in 2010\u20132012 to 72.4% in 2019\u20132021 and was less frequent among women aged \u2a7e35 years and those socioeconomically disadvantaged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Despite MS therapeutic management adaptations to pregnancy, exposure during pregnancy to treatments whose safety profile has not yet been clearly established has increased sharply over the last decade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585231223395","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T01:07:20Z","timestamp":1706404040000},"page":"227-237","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Use of multiple sclerosis disease-modifying therapies during pregnancy in France: Nationwide study between 2010 and 2021"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0159-0789","authenticated-orcid":false,"given":"Morgane","family":"Swital","sequence":"first","affiliation":[{"name":"EPI-PHARE Scientific Interest Group in Epidemiology of Health Products (French National Agency for the Safety of Medicines and Health Products-ANSM, French National Health Insurance-CNAM), Saint-Denis, France"},{"name":"French National Institute of Health and Medical Research (INSERM), Department of Social Epidemiology (ERES), Pierre Louis Institute for Epidemiology and Public Health (IPLESP), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Drouin","sequence":"additional","affiliation":[{"name":"EPI-PHARE Scientific Interest Group in Epidemiology of Health Products (French National Agency for the Safety of Medicines and Health Products-ANSM, French National Health Insurance-CNAM), Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Miranda","sequence":"additional","affiliation":[{"name":"EPI-PHARE Scientific Interest Group in Epidemiology of Health Products (French National Agency for the Safety of Medicines and Health Products-ANSM, French National Health Insurance-CNAM), Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Bakchine","sequence":"additional","affiliation":[{"name":"University of Reims Champagne Ardennes (URCA), Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4814-6370","authenticated-orcid":false,"given":"J\u00e9r\u00e9mie","family":"Botton","sequence":"additional","affiliation":[{"name":"EPI-PHARE Scientific Interest Group in Epidemiology of Health Products (French National Agency for the Safety of Medicines and Health Products-ANSM, French National Health Insurance-CNAM), Saint-Denis, France"},{"name":"Faculty of Pharmacy, Paris-Saclay University, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7646-3667","authenticated-orcid":false,"given":"Rosemary","family":"Dray-Spira","sequence":"additional","affiliation":[{"name":"EPI-PHARE Scientific Interest Group in Epidemiology of Health Products (French National Agency for the Safety of Medicines and Health Products-ANSM, French National Health Insurance-CNAM), Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"bibr1-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2015.10.006"},{"key":"bibr2-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.26858"},{"key":"bibr3-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520970841"},{"key":"bibr4-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.05.049"},{"key":"bibr5-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2022.2061950"},{"key":"bibr6-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00556-y"},{"key":"bibr7-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221129472"},{"key":"bibr8-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2020.05.005"},{"key":"bibr9-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2018-002060"},{"key":"bibr10-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5411"},{"key":"bibr11-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.01.003"},{"key":"bibr12-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104526"},{"key":"bibr13-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231161492"},{"key":"bibr14-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15559"},{"key":"bibr15-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012084"},{"key":"bibr16-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4556"},{"key":"bibr17-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007696"},{"key":"bibr18-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74409-x"},{"key":"bibr19-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245854"},{"key":"bibr20-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15638"},{"key":"bibr21-13524585231223395","doi-asserted-by":"publisher","DOI":"10.7326\/M22-0819"},{"key":"bibr22-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2023.2900"},{"key":"bibr23-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad266"},{"key":"bibr24-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.4905"},{"key":"bibr25-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211035376"},{"key":"bibr26-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1177\/17562864211054956"},{"key":"bibr27-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511422244"},{"key":"bibr28-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005347"},{"key":"bibr29-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2023.107673"},{"key":"bibr30-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.06.006"},{"key":"bibr31-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8513-0"},{"key":"bibr32-13524585231223395","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000717"},{"key":"bibr33-13524585231223395","unstructured":"OFSEP. Descriptif de la cohorte, https:\/\/www.ofsep.org\/fr\/la-cohorte-ofsep\/descriptif-de-la-cohorte (accessed 8 February 2023)."}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231223395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585231223395","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585231223395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:14:05Z","timestamp":1777695245000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585231223395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,27]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1177\/13524585231223395"],"URL":"https:\/\/doi.org\/10.1177\/13524585231223395","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,27]]}}}