{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:16:05Z","timestamp":1792286165909,"version":"4.4.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"4-5","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000924","name":"Multiple Sclerosis Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objective:<\/jats:title>\n                    <jats:p>We explored dynamic changes in the choroid plexus (CP) in patients with relapsing-remitting multiple sclerosis (RRMS) and assessed its relationship with chronic lesion expansion and atrophy in various brain compartments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifty-seven RRMS patients were annually assessed for a minimum of 48 months with 3D FLAIR, pre- and post-contrast 3D T1 and diffusion-weighted magnetic resonance imaging (MRI). The CP was manually segmented at baseline and last follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The volume of CP significantly increased by 1.4% annually. However, the extent of CP enlargement varied considerably among individuals (ranging from \u22123.6 to 150.8 mm\n                      <jats:sup>3<\/jats:sup>\n                      or \u22120.2% to 6.3%). The magnitude of CP enlargement significantly correlated with central (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.70,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and total brain atrophy (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.57,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), white (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.61,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and deep grey matter atrophy (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.60,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). Progressive CP enlargement was significantly associated with the volume and extent of chronic lesion expansion (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.60,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), but not with the number or volume of new lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study provides evidence of progressive CP enlargement in patients with RRMS. Our findings also demonstrate that enlargement of the CP volume is linked to the expansion of chronic lesions and neurodegeneration of periventricular white and grey matter in RRMS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241228423","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T06:41:03Z","timestamp":1707201663000},"page":"496-504","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Longitudinal enlargement of choroid plexus is associated with chronic lesion expansion and neurodegeneration in RRMS patients"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-5178","authenticated-orcid":false,"given":"Samuel","family":"Klistorner","sequence":"first","affiliation":[{"name":"Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-8864","authenticated-orcid":false,"given":"Michael H","family":"Barnett","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia"},{"name":"Sydney Neuroimaging Analysis Centre, Camperdown, NSW, Australia; Royal Prince Alfred Hospital, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia\/Sydney Neuroimaging Analysis Centre, Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Parratt","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Con","family":"Yiannikas","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Klistorner","sequence":"additional","affiliation":[{"name":"Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200144"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1636-z"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz212"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520974357"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2025000118"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021204426"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2115221118"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51644"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231157206"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200026"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001147"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117026"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.12.010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.346471"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2020-0267"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221111684"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13162668"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201608"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00903-y"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00903-y"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2019.08.007"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.04.035"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac334"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001160"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121738"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1001-9"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00822840"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104740"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011700"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22230"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25786"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26657"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221080667"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.734992"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.mp.2020-0016"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1290-2"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103368"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28937."}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585241228423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585241228423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585241228423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:14:17Z","timestamp":1777695257000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585241228423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":39,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1177\/13524585241228423"],"URL":"https:\/\/doi.org\/10.1177\/13524585241228423","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.08.06.23293738","asserted-by":"object"}]},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]}}}