{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:18Z","timestamp":1787019138809,"version":"build-2736575974"},"reference-count":47,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ministry of Health and Welfare, Republic of Korea","award":["HC23C0249000023"],"award-info":[{"award-number":["HC23C0249000023"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We investigated the risks of depression\/anxiety in patients with multiple sclerosis (pwMS) or patients with neuromyelitis optica spectrum disorder (pwNMOSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>MS\/NMOSD cohorts were collected from Korean National Health Insurance Service, using the International Classification of Diseases-10th and information on Rare Intractable Disease program. Patients who were younger than 20 years, had a previous depression\/anxiety, or died in the index year were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Hazard ratios (HRs) of depression\/anxiety in pwMS and pwNMOSD from controls matched 1:5 for age, sex, hypertension, diabetes, and dyslipidemia were calculated using Cox regressions with a 1-year lag period and estimated over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>During a mean follow-up of 4.1 years, adjusted hazard ratios (aHR) for depression were 3.25 (95% confidence interval (CI) = 2.59\u20134.07) in MS and 2.17 (1.70\u20132.76) in NMOSD, and aHRs for anxiety were 1.83 (1.49\u20132.23) in MS and 1.56 (1.26\u20131.91) in NMOSD. The risks of anxiety\/depression did not differ between MS and NMOSD and were highest in the second year after diagnosis of MS\/NMOSD. The relative risk of depression was higher in younger pwMS\/pwNMOSD, and the relative risk of anxiety was higher in pwMS who was male, had low income, or lived in a non-urban area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The risk of depression and anxiety was increased in pwMS\/pwNMOSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241237093","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T01:40:21Z","timestamp":1712022021000},"page":"714-725","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk of depression and anxiety in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5578-7571","authenticated-orcid":false,"given":"Soonwook","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Neurology, Inha University Hospital, Inha University College of Medicine, Incheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Do","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science, Soongsil University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The Catholic University of Korea, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Bin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, South Korea"},{"name":"Department of Neurology, Gyeongsang National University Changwon Hospital, Changwon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7052-2432","authenticated-orcid":false,"given":"Yeon Hak","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hea Lim","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"},{"name":"Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, South Korea"},{"name":"Depression Center, Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"},{"name":"Department of Clinical Research Design and Evaluation and Department 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