{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:22:09Z","timestamp":1791843729296,"version":"4.3.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The double-blind TERIKIDS study demonstrated the efficacy and safety of teriflunomide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the efficacy, safety, and tolerability of continuous teriflunomide treatment in the TERIKIDS open-label extension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In the double-blind period, children with relapsing MS were randomized to placebo or teriflunomide (14\u2009mg adult-equivalent dose) for\u2009\u2a7d\u200996\u2009weeks. Participants received teriflunomide for\u2009\u2a7d\u2009192\u2009weeks post-randomization in the open-label extension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean age at screening was 14.6\u2009years. For teriflunomide\/teriflunomide versus placebo\/teriflunomide, estimated clinical relapse risk was reduced by 38% (hazard ratio (HR) 0.62; 95% confidence interval (CI) 0.39\u20130.98; p\u2009=\u20090.11) and numbers of gadolinium-enhancing T1 and new\/enlarging T2 lesions were reduced by 43% (relative risk (RR) 0.570; 95% CI 0.33\u20130.98; p\u2009=\u20090.043) and 49% (RR 0.511; 95% CI 0.34\u20130.76; p\u2009=\u20090.001), respectively, in the combined double-blind and open-label periods. There was a trend toward reduced risk of 24-week sustained disability progression for teriflunomide\/teriflunomide versus placebo\/teriflunomide (HR 0.47; 95% CI 0.23\u20130.96). During the open-label extension, incidences of safety-related discontinuations were 4.0% (teriflunomide\/teriflunomide) and 13.5% (placebo\/teriflunomide), including two children who developed pancreatitis in the teriflunomide\/teriflunomide group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Teriflunomide reduced the long-term risk of focal inflammatory activity, with generally manageable tolerability and no new safety signals. Further evidence would strengthen clinical efficacy findings. ClinicalTrials.gov: NCT02201108.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241242050","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T06:43:47Z","timestamp":1713163427000},"page":"833-842","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Teriflunomide in pediatric patients with relapsing multiple sclerosis: Open-label extension of TERIKIDS"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-4422","authenticated-orcid":false,"given":"Tanuja","family":"Chitnis","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital for Children, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Banwell","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-5509","authenticated-orcid":false,"given":"Ludwig","family":"Kappos","sequence":"additional","affiliation":[{"name":"Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University of Basel, Basel, Switzerland\/MS Center and Neurologic Clinic and Policlinic, Departments of Biomedicine and Clinical Research, University Hospital of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-0106","authenticated-orcid":false,"given":"Douglas L","family":"Arnold","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute, McGill University, Montr\u00e9al, QC, Canada"},{"name":"NeuroRx Research, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kivilcim","family":"G\u00fcc\u00fcyener","sequence":"additional","affiliation":[{"name":"Gazi Universitesi Tip Fakultesi Pediatrik N\u00f6roloji Bilim Dali, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumaran","family":"Deiva","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Assistance Publique-H\u00f4pitaux de Paris, University Hospitals Paris Saclay, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Saubadu","sequence":"additional","affiliation":[{"name":"Sanofi, Chilly-Mazarin, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenruo","family":"Hu","sequence":"additional","affiliation":[{"name":"Sanofi, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Benamor","sequence":"additional","affiliation":[{"name":"Sanofi, 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