{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:57:55Z","timestamp":1792799875303,"version":"4.5.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Health and Labour Sciences Research Grant on Intractable Diseases (Neuroimmunological Diseases) from the Ministry of Health, Labour and Welfare of Japan","award":["23FC1009"],"award-info":[{"award-number":["23FC1009"]}],"id":[{"id":"https:\/\/ror.org\/03mwa7s65","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Myelin oligodendrocyte glycoprotein antibody\u2013associated disease (MOGAD) is a rare neuroinflammatory disorder characterized by acute episodes of central nervous system (CNS) demyelination. Previous studies have reported elevated interleukin (IL)-6 in cerebrospinal fluid (CSF) of MOGAD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We examined if CSF IL-6 level increase is associated with clinical parameters in MOGAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>IL-6 levels were measured using 44 CSF samples during the acute phase and 6 samples during recovery from 34 MOGAD patients, as well as 65 CSF samples from 45 aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4Ab + NMOSD), 107 samples from 76 multiple sclerosis patients, and 45 samples from neurodegenerative disease patients. Associations between IL-6 levels and clinical parameters in MOGAD were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>CSF IL-6 levels were significantly comparably elevated during acute-phase in MOGAD and AQP4Ab + NMOSD, but declined following the acute phase. Among MOGAD patients, CSF IL-6 level was significantly correlated with CSF cell count, greater in patients with brain lesions than spinal cord lesions, and higher in CSF than serum, suggesting that excessive IL-6 is produced predominantly in CNS. Neurological recovery was tended to be poorer in MOGAD patients with higher CSF IL-6 level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CSF IL-6 may play important roles in the pathogenesis of MOGAD, especially in CNS inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241254731","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T01:39:00Z","timestamp":1716514740000},"page":"977-982","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Contributions of CSF interleukin-6 elevation to the pathogenesis of myelin oligodendrocyte glycoprotein antibody\u2013associated disease"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-1863","authenticated-orcid":false,"given":"Akiyuki","family":"Uzawa","sequence":"first","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-255X","authenticated-orcid":false,"given":"Masahiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-6482","authenticated-orcid":false,"given":"Hiroki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-341X","authenticated-orcid":false,"given":"Ryohei","family":"Ohtani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Chiba University Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"bibr1-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00431-8"},{"key":"bibr2-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231156736"},{"key":"bibr3-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115806"},{"key":"bibr4-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001076"},{"key":"bibr5-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1637-7"},{"key":"bibr6-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149411"},{"key":"bibr7-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.10.002"},{"key":"bibr8-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-317969"},{"key":"bibr9-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2019.577021"},{"key":"bibr10-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.03.006"},{"key":"bibr11-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017385108"},{"key":"bibr12-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1111\/cen3.12024"},{"key":"bibr13-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901747"},{"key":"bibr14-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001100"},{"key":"bibr15-13524585241254731","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200150"},{"key":"bibr16-13524585241254731","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1037812"}],"container-title":["Multiple 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