{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:50:33Z","timestamp":1792443033199,"version":"4.5.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The Konectom\u2122 smartphone-based cognitive processing speed (CPS) test is designed to assess processing speed and account for impact of visuomotor function on performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Evaluate reliability and validity of Konectom CPS Test, performed in clinic and remotely.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data were collected from people with multiple sclerosis (PwMS) aged 18\u201364 years and healthy control participants (HC) matched for age, sex, and education. Remote test\u2013retest reliability (intraclass correlation coefficients, ICC); correlation with established clinical measures (Spearman correlation coefficients); group analyses between cognitively impaired\/unimpaired PwMS; and influence of age, sex, education, and upper limb motor function on CPS Test measures were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eighty PwMS and 66 HC participated. CPS Test measures from remote tests had good test\u2013retest reliability (ICC of 0.67\u20130.87) and correlated with symbol digit modalities test (highest |\u03c1| = 0.80, p &lt; 0.0001). Remote measures were stable (change from baseline &lt; 5%) and correlated with MS disability (highest |\u03c1| = 0.39, p = 0.0004) measured by Expanded Disability Status Scale. CPS Test measures displayed sensitivity to cognitive impairment (highest d = 1.47). Demographics and motor function had the lowest impact on CPS Test substitution time, a measure accounting for visuomotor function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Konectom CPS Test measures provide valid, reliable remote measurements of cognitive processing speed in PwMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241259650","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T08:47:55Z","timestamp":1719218875000},"page":"1193-1204","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Konectom\u2122 cognitive processing speed test enables reliable remote, unsupervised cognitive assessment in people with multiple sclerosis: Exploring the use of substitution time as a novel digital outcome measure"],"prefix":"10.1177","volume":"30","author":[{"given":"Matthew","family":"Scaramozza","sequence":"first","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia A","family":"Chiesa","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Zajac","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaonan","family":"Sun","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minao","family":"Tang","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Juraver","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bartholom\u00e9","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Charr\u00e9-Morin","sequence":"additional","affiliation":[{"name":"Neurology Department, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Saubusse","sequence":"additional","affiliation":[{"name":"Neurology Department, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling C","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine-Geriatrics, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-2796","authenticated-orcid":false,"given":"Bruno","family":"Brochet","sequence":"additional","affiliation":[{"name":"U1215 INSERM, University of Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Carment","sequence":"additional","affiliation":[{"name":"Ad Scientiam, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Biogen, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolan","family":"Campbell","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-8739","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Ruet","sequence":"additional","affiliation":[{"name":"Neurology Department, CHU de Bordeaux, Bordeaux, France; 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